DegronMD

Uniprot ID: Q86UB2

Source protein: Basic immunoglobulin-like variable motif-containing protein

Source gene: BIVM

Class: DEG_SPOP_SBC_1

Location: 95:99

E3 ligase: SPOP

DEGRON score: 0.8253

ASA_SCORE: 79.44

COIL: 0.82

CONS_SCORE: 0.4723

DSS_SCORE: 0.5429

HELIX: 0.1526

FCONS_SCORE: 0.9662

RIG_SCORE: 0.6947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P92L	DO220851	MELA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.25
p.P108L	DO220899	MELA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.0833
p.I102N	DO224596	PACA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.25
p.N104Y	DO38727	STAD	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1944
p.R90H	DO38195	STAD	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1944
p.R90H	DO42033	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1944
p.L100F	DO50076	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	0.3056
p.E105K	DO41020	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1667
p.E105K	DO41211	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1667
p.G103V	SIDM01095	Rhabdomyosarcoma	GDSC	PDSTS	DEG_SPOP_SBC_1	0.2222
p.G103V	SJRH30	soft_tissue	COSMIC	PDSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_SPOP_SBC_1	3322:3326	PDSTS	SPOP	0.978	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	203:207	PDSTS	SPOP	0.9977	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	1438:1442	PDSTS	SPOP	0.8768	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	692:696	PDSTS	SPOP	0.9972	More...
Q9Y2J4	Angiomotin-like protein 2	DEG_SPOP_SBC_1	734:738	PDSTS	SPOP	0.9907	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SPOP_SBC_1	615:619	PDSTS	SPOP	0.585	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	95:99	PDSTS	SPOP	0.8253	More...
Q96SK2	Transmembrane protein 209	DEG_SPOP_SBC_1	261:265	PDSTS	SPOP	0.9778	More...
Q8N446	Zinc finger protein 843	DEG_SPOP_SBC_1	190:194	PDSTS	SPOP	0.8804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons