DegronMD - O95613(PCNT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E599Q	TCGA-77-8136	LUSC	TCGA	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.2778
p.E599Q	DO26593	LUSC	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.2778
p.E984K	TCGA-78-7154	LUAD	TCGA	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation rewiring degron network	0.2778
p.E984K	DO24070	LUAD	ICGC	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation rewiring degron network	0.2778
p.A595V	TCGA-A5-A0VP	UCEC	TCGA	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1667
p.A595V	DO42600	UCEC	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1667
p.A595V	SIDM00435	Acute Myeloid Leukemia	GDSC	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1667
p.A595V	SIDM00628	Breast Carcinoma	GDSC	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1667
p.A249V	TCGA-A6-6780	COAD	TCGA	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.3056
p.A249V	TCGA-FI-A2D5	UCEC	TCGA	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.3056
p.A249V	DO10244	COAD	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.3056
p.A249V	DO41331	UCEC	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.3056
p.A249V	SIDM01943	Colorectal Carcinoma	GDSC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.3056
p.D2112G	TCGA-AP-A054	UCEC	TCGA	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.0556
p.D2112G	DO42256	UCEC	ICGC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.0556
p.R983C	TCGA-AX-A1CE	UCEC	TCGA	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation rewiring degron network	0.25
p.R983C	DO42280	UCEC	ICGC	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation rewiring degron network	0.25
p.T3325A	TCGA-AZ-6598	COAD	TCGA	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation altering degron motif	0.7139
p.T3325A	DO10276	COAD	ICGC	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation altering degron motif	0.7139
p.Q3314R	TCGA-BG-A222	UCEC	TCGA	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation rewiring degron network	0.1111
p.Q3314R	DO42977	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation rewiring degron network	0.1111
p.H243Y	TCGA-CM-4746	COAD	TCGA	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.1389
p.H243Y	DO7882	COAD	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.1389
p.W1002C	TCGA-D1-A15X	UCEC	TCGA	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation rewiring degron network	0.1111
p.W1002C	DO43274	UCEC	ICGC	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation rewiring degron network	0.1111
p.L612I	TCGA-D3-A2JO	SKCM	TCGA	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.25
p.L612I	DO47619	SKCM	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.25
p.Q3314K	TCGA-EE-A17Z	SKCM	TCGA	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation rewiring degron network	0.1111
p.Q3314K	DO37921	SKCM	ICGC	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation rewiring degron network	0.1111
p.V3312L	TCGA-EE-A3AD	SKCM	TCGA	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation rewiring degron network	0.0556
p.V3312L	DO37707	SKCM	ICGC	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation rewiring degron network	0.0556
p.H619Y	TCGA-EY-A1GQ	UCEC	TCGA	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0556
p.H619Y	DO43090	UCEC	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0556
p.G2117R	TCGA-FI-A2D5	UCEC	TCGA	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.1944
p.G2117R	DO41331	UCEC	ICGC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.1944
p.T2135M	TCGA-VQ-A91D	STAD	TCGA	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.1111
p.T2135M	DO51783	STAD	ICGC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.1111
p.T2135M	SIDM01113	Other Sarcomas	GDSC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.1111
p.T2135M	ACH-000939	Sarcoma	CCLE	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.1111
p.T2135M	SK-UT-1	soft tissue	COSMIC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.1111
p.S2114F	TCGA-XF-A9ST	BLCA	TCGA	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation blocking phosphorylation signal	0.5556
p.S2114F	DO223599	BLCA	ICGC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation blocking phosphorylation signal	0.5556
p.V242L	DO225105	BRCA	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.1111
p.E2119K	DO227470	BRCA	ICGC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.25
p.Q396K	DO10172	COAD	ICGC	QRAELEKIF	DEG_APCC_DBOX_1	387:395	Mutation rewiring degron network	0.3056
p.Q988L	DO50392	ESAD	ICGC	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation altering degron motif	0.6654
p.E998G	DO223048	ESCA	ICGC	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation rewiring degron network	0.2222
p.A267T	DO231957	LICA	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.0833
p.V3320L	DO229018	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	3322:3326	Mutation rewiring degron network	0.2778
p.Q615H	DO229009	LICA	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1667
p.H2125P	DO230993	LUSC	ICGC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation altering degron motif	0.7694
p.H2125P	DO230990	LUSC	ICGC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation altering degron motif	0.7694
p.G244C	DO52389	LUSC	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.1667
p.R251C	DO232761	PBCA	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.8301
p.S255I	DO229272	THCA	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.7341
p.T259M	SIDM00999	Bladder Carcinoma	GDSC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation blocking phosphorylation signal	0.75
p.T259M	ACH-000973	Bladder Cancer	CCLE	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation blocking phosphorylation signal	0.75
p.K1003E	SIDM00999	Bladder Carcinoma	GDSC	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation substituting flanking lysine	0.1944
p.K1003E	ACH-000973	Bladder Cancer	CCLE	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation substituting flanking lysine	0.1944
p.K1003E	639-V	urinary tract	COSMIC	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation substituting flanking lysine	0.1944
p.Q261E	SIDM00870	Breast Carcinoma	GDSC	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.25
p.Q261E	ACH-000725	Breast Cancer	CCLE	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.25
p.K1004N	SIDM01588	Endometrial Carcinoma	GDSC	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation blocking ubiquitination signal	0.5
p.K1004N	ACH-000993	Endometrial/Uterine Cancer	CCLE	HRQALELLR	DEG_APCC_DBOX_1	986:994	Mutation blocking ubiquitination signal	0.5
p.N268S	ACH-000598	Myeloma	CCLE	LRLSLSNMH	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.0556
p.E2118G	ACH-002258	Leukemia	CCLE	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.2222
p.E2118G	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	ISPHID	LIG_APCC_ABBA_1	2122:2127	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCNT

UniProt ID: O95613

Entrez ID: 5116

Protein name: Pericentrin (Kendrin) (Pericentrin-B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCNT in