DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
QRAELEKIF
Uniprot ID:
O95613
Source protein:
Pericentrin
Source gene:
PCNT
Class:
DEG_APCC_DBOX_1
Location:
387:395
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6107
ASA_SCORE:
108.6667
COIL:
0.0646
CONS_SCORE:
0.5796
DSS_SCORE:
0.445
HELIX:
0.9367
FCONS_SCORE:
1.1391
RIG_SCORE:
0.7851
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q396K
DO10172
COAD
ICGC
QRAELEKIF
DEG_APCC_DBOX_1
0.3056
Drug responses associated with PCNT mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRAELEKIF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95613
Pericentrin
DEG_APCC_DBOX_1
387:395
QRAELEKIF
APC,CDC20,FZR1
0.6107
More...