DegronMD

Uniprot ID: O95613

Source protein: Pericentrin

Source gene: PCNT

Class: LIG_APCC_ABBA_1

Location: 2122:2127

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.984

ASA_SCORE: 109.0667

COIL: 0.8635

CONS_SCORE: 0.5145

DSS_SCORE: 0.5047

HELIX: 0.109

FCONS_SCORE: 1.1358

RIG_SCORE: 0.7327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2112G	TCGA-AP-A054	UCEC	TCGA	ISPHID	LIG_APCC_ABBA_1	0.0556
p.D2112G	DO42256	UCEC	ICGC	ISPHID	LIG_APCC_ABBA_1	0.0556
p.G2117R	TCGA-FI-A2D5	UCEC	TCGA	ISPHID	LIG_APCC_ABBA_1	0.1944
p.G2117R	DO41331	UCEC	ICGC	ISPHID	LIG_APCC_ABBA_1	0.1944
p.T2135M	TCGA-VQ-A91D	STAD	TCGA	ISPHID	LIG_APCC_ABBA_1	0.1111
p.T2135M	DO51783	STAD	ICGC	ISPHID	LIG_APCC_ABBA_1	0.1111
p.T2135M	SIDM01113	Other Sarcomas	GDSC	ISPHID	LIG_APCC_ABBA_1	0.1111
p.T2135M	ACH-000939	Sarcoma	CCLE	ISPHID	LIG_APCC_ABBA_1	0.1111
p.T2135M	SK-UT-1	soft_tissue	COSMIC	ISPHID	LIG_APCC_ABBA_1	0.1111
p.S2114F	TCGA-XF-A9ST	BLCA	TCGA	ISPHID	LIG_APCC_ABBA_1	0.5556
p.S2114F	DO223599	BLCA	ICGC	ISPHID	LIG_APCC_ABBA_1	0.5556
p.E2119K	DO227470	BRCA	ICGC	ISPHID	LIG_APCC_ABBA_1	0.25
p.H2125P	DO230993	LUSC	ICGC	ISPHID	LIG_APCC_ABBA_1	0.7694
p.H2125P	DO230990	LUSC	ICGC	ISPHID	LIG_APCC_ABBA_1	0.7694
p.E2118G	ACH-002258	Leukemia	CCLE	ISPHID	LIG_APCC_ABBA_1	0.2222
p.E2118G	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	ISPHID	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	LIG_APCC_ABBA_1	2122:2127	ISPHID	APC,CDC20,FZR1	0.984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons