DegronMD

Uniprot ID: O95613

Source protein: Pericentrin

Source gene: PCNT

Class: DEG_APCC_DBOX_1

Location: 601:609

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8686

ASA_SCORE: 113.2333

COIL: 0.1587

CONS_SCORE: 0.3547

DSS_SCORE: 0.4023

HELIX: 0.8394

FCONS_SCORE: 1.3606

RIG_SCORE: 0.7239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E599Q	TCGA-77-8136	LUSC	TCGA	HRHQLEALE	DEG_APCC_DBOX_1	0.2778
p.E599Q	DO26593	LUSC	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	0.2778
p.A595V	TCGA-A5-A0VP	UCEC	TCGA	HRHQLEALE	DEG_APCC_DBOX_1	0.1667
p.A595V	DO42600	UCEC	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	0.1667
p.A595V	SIDM00435	Acute Myeloid Leukemia	GDSC	HRHQLEALE	DEG_APCC_DBOX_1	0.1667
p.A595V	SIDM00628	Breast Carcinoma	GDSC	HRHQLEALE	DEG_APCC_DBOX_1	0.1667
p.L612I	TCGA-D3-A2JO	SKCM	TCGA	HRHQLEALE	DEG_APCC_DBOX_1	0.25
p.L612I	DO47619	SKCM	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	0.25
p.H619Y	TCGA-EY-A1GQ	UCEC	TCGA	HRHQLEALE	DEG_APCC_DBOX_1	0.0556
p.H619Y	DO43090	UCEC	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	0.0556
p.Q615H	DO229009	LICA	ICGC	HRHQLEALE	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_APCC_DBOX_1	601:609	HRHQLEALE	APC,CDC20,FZR1	0.8686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons