DegronMD

Uniprot ID: O95613

Source protein: Pericentrin

Source gene: PCNT

Class: DEG_APCC_DBOX_1

Location: 986:994

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5735

ASA_SCORE: 105.7222

COIL: 0.0176

CONS_SCORE: 0.7315

DSS_SCORE: 0.1777

HELIX: 0.9832

FCONS_SCORE: 1.2072

RIG_SCORE: 0.8412

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E984K	TCGA-78-7154	LUAD	TCGA	HRQALELLR	DEG_APCC_DBOX_1	0.2778
p.E984K	DO24070	LUAD	ICGC	HRQALELLR	DEG_APCC_DBOX_1	0.2778
p.R983C	TCGA-AX-A1CE	UCEC	TCGA	HRQALELLR	DEG_APCC_DBOX_1	0.25
p.R983C	DO42280	UCEC	ICGC	HRQALELLR	DEG_APCC_DBOX_1	0.25
p.W1002C	TCGA-D1-A15X	UCEC	TCGA	HRQALELLR	DEG_APCC_DBOX_1	0.1111
p.W1002C	DO43274	UCEC	ICGC	HRQALELLR	DEG_APCC_DBOX_1	0.1111
p.Q988L	DO50392	ESAD	ICGC	HRQALELLR	DEG_APCC_DBOX_1	0.6654
p.E998G	DO223048	ESCA	ICGC	HRQALELLR	DEG_APCC_DBOX_1	0.2222
p.K1003E	SIDM00999	Bladder Carcinoma	GDSC	HRQALELLR	DEG_APCC_DBOX_1	0.1944
p.K1003E	ACH-000973	Bladder Cancer	CCLE	HRQALELLR	DEG_APCC_DBOX_1	0.1944
p.K1003E	639-V	urinary_tract	COSMIC	HRQALELLR	DEG_APCC_DBOX_1	0.1944
p.K1004N	SIDM01588	Endometrial Carcinoma	GDSC	HRQALELLR	DEG_APCC_DBOX_1	0.5
p.K1004N	ACH-000993	Endometrial/Uterine Cancer	CCLE	HRQALELLR	DEG_APCC_DBOX_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_APCC_DBOX_1	986:994	HRQALELLR	APC,CDC20,FZR1	0.5735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons