DegronMD

Uniprot ID: O95613

Source protein: Pericentrin

Source gene: PCNT

Class: DEG_SPOP_SBC_1

Location: 3322:3326

E3 ligase: SPOP

DEGRON score: 0.978

ASA_SCORE: 87.7

COIL: 0.8722

CONS_SCORE: 0.6808

DSS_SCORE: 0.5389

HELIX: 0.1088

FCONS_SCORE: 0.8698

RIG_SCORE: 0.6772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3325A	TCGA-AZ-6598	COAD	TCGA	PDSTS	DEG_SPOP_SBC_1	0.7139
p.T3325A	DO10276	COAD	ICGC	PDSTS	DEG_SPOP_SBC_1	0.7139
p.Q3314R	TCGA-BG-A222	UCEC	TCGA	PDSTS	DEG_SPOP_SBC_1	0.1111
p.Q3314R	DO42977	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1111
p.Q3314K	TCGA-EE-A17Z	SKCM	TCGA	PDSTS	DEG_SPOP_SBC_1	0.1111
p.Q3314K	DO37921	SKCM	ICGC	PDSTS	DEG_SPOP_SBC_1	0.1111
p.V3312L	TCGA-EE-A3AD	SKCM	TCGA	PDSTS	DEG_SPOP_SBC_1	0.0556
p.V3312L	DO37707	SKCM	ICGC	PDSTS	DEG_SPOP_SBC_1	0.0556
p.V3320L	DO229018	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_SPOP_SBC_1	3322:3326	PDSTS	SPOP	0.978	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	203:207	PDSTS	SPOP	0.9977	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	1438:1442	PDSTS	SPOP	0.8768	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	692:696	PDSTS	SPOP	0.9972	More...
Q9Y2J4	Angiomotin-like protein 2	DEG_SPOP_SBC_1	734:738	PDSTS	SPOP	0.9907	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SPOP_SBC_1	615:619	PDSTS	SPOP	0.585	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	95:99	PDSTS	SPOP	0.8253	More...
Q96SK2	Transmembrane protein 209	DEG_SPOP_SBC_1	261:265	PDSTS	SPOP	0.9778	More...
Q8N446	Zinc finger protein 843	DEG_SPOP_SBC_1	190:194	PDSTS	SPOP	0.8804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons