DegronMD - Q8N446(ZNF843)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G203R	TCGA-A2-A04V	BRCA	TCGA	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0833
p.G203R	DO1532	BRCA	ICGC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0833
p.G203R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0833
p.A189T	TCGA-AA-A01P	COAD	TCGA	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.A189T	DO8642	COAD	ICGC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.L196I	TCGA-FI-A2D5	UCEC	TCGA	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.L196I	DO41331	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.S194Y	DO227987	COCA	ICGC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.712
p.G200E	DO233207	GACA	ICGC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1667
p.S182R	DO228948	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.P185T	DO228952	LICA	ICGC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1944
p.R197W	SIDM02074	Esophageal Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.25
p.R197W	ACH-000941	Endometrial/Uterine Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.25
p.R197W	ACH-000954	Endometrial/Uterine Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.25
p.R197W	ACH-001517	Endometrial/Uterine Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons