DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_SPOP_SBC_1

Location: 692:696

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 89

COIL: 0.9284

CONS_SCORE: 0.3747

DSS_SCORE: 0.4763

HELIX: 0.0322

FCONS_SCORE: 0.9867

RIG_SCORE: 0.6728

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P692Q	TCGA-77-6842	LUSC	TCGA	PDSTS	DEG_SPOP_SBC_1	0.7035
p.P692Q	DO27413	LUSC	ICGC	PDSTS	DEG_SPOP_SBC_1	0.7035
p.S687R	SIDM01503	Small Cell Lung Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_SPOP_SBC_1	3322:3326	PDSTS	SPOP	0.978	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	203:207	PDSTS	SPOP	0.9977	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	1438:1442	PDSTS	SPOP	0.8768	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	692:696	PDSTS	SPOP	0.9972	More...
Q9Y2J4	Angiomotin-like protein 2	DEG_SPOP_SBC_1	734:738	PDSTS	SPOP	0.9907	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SPOP_SBC_1	615:619	PDSTS	SPOP	0.585	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	95:99	PDSTS	SPOP	0.8253	More...
Q96SK2	Transmembrane protein 209	DEG_SPOP_SBC_1	261:265	PDSTS	SPOP	0.9778	More...
Q8N446	Zinc finger protein 843	DEG_SPOP_SBC_1	190:194	PDSTS	SPOP	0.8804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons