DegronMD - Q86UB2(BIVM)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A79V	DO225185	BRCA	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.25
p.A79V	DO227815	BRCA	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.25
p.A79S	DO2665	BRCA	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.25
p.P88A	DO51642	CESC	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.6392
p.G118E	DO7962	COAD	ICGC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.3056
p.P113L	DO233748	GACA	ICGC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7582
p.P113L	DO42665	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7582
p.P92L	DO220851	MELA	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.25
p.P92L	DO220851	MELA	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.25
p.P108L	DO220899	MELA	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0833
p.P108L	DO220899	MELA	ICGC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1944
p.I102N	DO224596	PACA	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.25
p.T85N	DO50287	SKCM	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.7055
p.S87L	DO51291	SKCM	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.7667
p.N104Y	DO38727	STAD	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.N104Y	DO38727	STAD	ICGC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0833
p.R90H	DO38195	STAD	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.3056
p.R90H	DO38195	STAD	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.R90H	DO42033	UCEC	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.3056
p.R90H	DO42033	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1944
p.K113Q	DO219773	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.6944
p.L100F	DO50076	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.3056
p.R81H	DO50078	UCEC	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.3056
p.E105K	DO41020	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.E105K	DO41020	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1111
p.E105K	DO41211	UCEC	ICGC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.E105K	DO41211	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1111
p.I82V	SIDM00395	Neuroblastoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM00422	Hodgkin's Lymphoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM01649	Non-Cancerous	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM01203	Other Solid Cancers	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM00941	Kidney Carcinoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM00685	Glioblastoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM00220	Ovarian Carcinoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM00261	Ewing's Sarcoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM00184	Melanoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.I82V	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.5965
p.P86S	SIDM00422	Hodgkin's Lymphoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.6752
p.P86S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	IYKTPNPS	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.6752
p.G103V	SIDM01095	Rhabdomyosarcoma	GDSC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.2222
p.G103V	SIDM01095	Rhabdomyosarcoma	GDSC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.G103V	SJRH30	soft tissue	COSMIC	PDSTS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.2222
p.G103V	SJRH30	soft tissue	COSMIC	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.E123K	ACH-002039	Pancreatic Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BIVM

UniProt ID: Q86UB2

Entrez ID: 54841

Protein name: Basic immunoglobulin-like variable motif-containing protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BIVM in