DegronMD

Uniprot ID: Q86UB2

Source protein: Basic immunoglobulin-like variable motif-containing protein

Source gene: BIVM

Class: DEG_SCF_FBW7_1

Location: 82:89

E3 ligase: FBXW7

DEGRON score: 0.6567

ASA_SCORE: 84.8

COIL: 0.7656

CONS_SCORE: 0.4854

DSS_SCORE: 0.4303

HELIX: 0.0339

FCONS_SCORE: 0.9759

RIG_SCORE: 0.7137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A79V	DO225185	BRCA	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.25
p.A79V	DO227815	BRCA	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.25
p.A79S	DO2665	BRCA	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.25
p.P88A	DO51642	CESC	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.6392
p.P92L	DO220851	MELA	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.25
p.T85N	DO50287	SKCM	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.7055
p.S87L	DO51291	SKCM	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.7667
p.R90H	DO38195	STAD	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.3056
p.R90H	DO42033	UCEC	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.3056
p.R81H	DO50078	UCEC	ICGC	IYKTPNPS	DEG_SCF_FBW7_1	0.3056
p.I82V	SIDM00395	Neuroblastoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM00422	Hodgkin's Lymphoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM01649	Non-Cancerous	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM01203	Other Solid Cancers	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM00941	Kidney Carcinoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM00685	Glioblastoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM00220	Ovarian Carcinoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM00261	Ewing's Sarcoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM00184	Melanoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.I82V	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.5965
p.P86S	SIDM00422	Hodgkin's Lymphoma	GDSC	IYKTPNPS	DEG_SCF_FBW7_1	0.6752
p.P86S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	IYKTPNPS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SCF_FBW7_1	82:89	IYKTPNPS	FBXW7	0.6567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons