DegronMD

Uniprot ID: P10914

Source protein: Interferon regulatory factor 1

Source gene: IRF1

Class: DEG_SPOP_SBC_1

Location: 203:207

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 78.82

COIL: 0.843

CONS_SCORE: 0.4798

DSS_SCORE: 0.3755

HELIX: 0.0816

FCONS_SCORE: 1.448

RIG_SCORE: 0.7425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E200D	TCGA-AB-2940	LAML	TCGA	PDSTS	DEG_SPOP_SBC_1	0.25
p.E200D	DO21773	LAML	ICGC	PDSTS	DEG_SPOP_SBC_1	0.25
p.D194V	TCGA-BR-7704	STAD	TCGA	PDSTS	DEG_SPOP_SBC_1	0.0833
p.D194V	DO38360	STAD	ICGC	PDSTS	DEG_SPOP_SBC_1	0.0833
p.L209V	TCGA-CF-A8HY	BLCA	TCGA	PDSTS	DEG_SPOP_SBC_1	0.2778
p.L209V	DO218998	BLCA	ICGC	PDSTS	DEG_SPOP_SBC_1	0.2778
p.Y210F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	0.25
p.Y210F	ACH-000904	Lung Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	0.25
p.Y210F	ACH-001362	Lung Cancer	CCLE	PDSTS	DEG_SPOP_SBC_1	0.25
p.Y210F	NCI-H1770	lung	COSMIC	PDSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_SPOP_SBC_1	3322:3326	PDSTS	SPOP	0.978	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	203:207	PDSTS	SPOP	0.9977	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	1438:1442	PDSTS	SPOP	0.8768	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	692:696	PDSTS	SPOP	0.9972	More...
Q9Y2J4	Angiomotin-like protein 2	DEG_SPOP_SBC_1	734:738	PDSTS	SPOP	0.9907	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SPOP_SBC_1	615:619	PDSTS	SPOP	0.585	More...
Q86UB2	Basic immunoglobulin-like variable motif-containing protein	DEG_SPOP_SBC_1	95:99	PDSTS	SPOP	0.8253	More...
Q96SK2	Transmembrane protein 209	DEG_SPOP_SBC_1	261:265	PDSTS	SPOP	0.9778	More...
Q8N446	Zinc finger protein 843	DEG_SPOP_SBC_1	190:194	PDSTS	SPOP	0.8804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons