DegronMD

Uniprot ID: O95613

Source protein: Pericentrin

Source gene: PCNT

Class: DEG_APCC_DBOX_1

Location: 250:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6744

ASA_SCORE: 102.4222

COIL: 0.2198

CONS_SCORE: 0.7778

DSS_SCORE: 0.2899

HELIX: 0.7743

FCONS_SCORE: 1.1142

RIG_SCORE: 0.7407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A249V	TCGA-A6-6780	COAD	TCGA	LRLSLSNMH	DEG_APCC_DBOX_1	0.3056
p.A249V	TCGA-FI-A2D5	UCEC	TCGA	LRLSLSNMH	DEG_APCC_DBOX_1	0.3056
p.A249V	DO10244	COAD	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	0.3056
p.A249V	DO41331	UCEC	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	0.3056
p.A249V	SIDM01943	Colorectal Carcinoma	GDSC	LRLSLSNMH	DEG_APCC_DBOX_1	0.3056
p.H243Y	TCGA-CM-4746	COAD	TCGA	LRLSLSNMH	DEG_APCC_DBOX_1	0.1389
p.H243Y	DO7882	COAD	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	0.1389
p.V242L	DO225105	BRCA	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	0.1111
p.A267T	DO231957	LICA	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	0.0833
p.G244C	DO52389	LUSC	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	0.1667
p.R251C	DO232761	PBCA	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	0.8301
p.S255I	DO229272	THCA	ICGC	LRLSLSNMH	DEG_APCC_DBOX_1	0.7341
p.T259M	SIDM00999	Bladder Carcinoma	GDSC	LRLSLSNMH	DEG_APCC_DBOX_1	0.75
p.T259M	ACH-000973	Bladder Cancer	CCLE	LRLSLSNMH	DEG_APCC_DBOX_1	0.75
p.Q261E	SIDM00870	Breast Carcinoma	GDSC	LRLSLSNMH	DEG_APCC_DBOX_1	0.25
p.Q261E	ACH-000725	Breast Cancer	CCLE	LRLSLSNMH	DEG_APCC_DBOX_1	0.25
p.N268S	ACH-000598	Myeloma	CCLE	LRLSLSNMH	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95613	Pericentrin	DEG_APCC_DBOX_1	250:258	LRLSLSNMH	APC,CDC20,FZR1	0.6744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons