DegronMD

Uniprot ID: Q6XZF7

Source protein: Dynamin-binding protein

Source gene: DNMBP

Class: DEG_SCF_FBW7_1

Location: 615:621

E3 ligase: FBXW7

DEGRON score: 0.9277

ASA_SCORE: 90.9143

COIL: 0.9573

CONS_SCORE: 0.2636

DSS_SCORE: 0.6862

HELIX: 0.0197

FCONS_SCORE: 0.9156

RIG_SCORE: 0.5956

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P623H	TCGA-A6-3809	COAD	TCGA	PCTPVST	DEG_SCF_FBW7_1	0.2778
p.P623H	DO8722	COAD	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.2778
p.Q629H	TCGA-B5-A11E	UCEC	TCGA	PCTPVST	DEG_SCF_FBW7_1	0.1111
p.Q629H	DO41644	UCEC	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.1111
p.P615S	TCGA-BF-A3DL	SKCM	TCGA	PCTPVST	DEG_SCF_FBW7_1	0.6752
p.P615S	DO51238	SKCM	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.6752
p.R614C	TCGA-C5-A1M8	CESC	TCGA	PCTPVST	DEG_SCF_FBW7_1	0.3056
p.R614C	DO48993	CESC	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.3056
p.P618L	TCGA-DD-AADG	LIHC	TCGA	PCTPVST	DEG_SCF_FBW7_1	0.7582
p.P618L	DO219571	LIHC	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.7582
p.K606N	TCGA-ER-A19T	SKCM	TCGA	PCTPVST	DEG_SCF_FBW7_1	0.1944
p.K606N	DO51251	SKCM	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.1944
p.P612A	DO223407	CLLE	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.25
p.F620L	DO8730	COAD	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.6981
p.P611L	DO233613	GACA	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.2222
p.P611L	DO220906	MELA	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.2222
p.T630I	DO220879	MELA	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.0833
p.P611S	DO220906	MELA	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.2222
p.P623L	DO229502	SKCA	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.2778
p.S611Y	DO41361	UCEC	ICGC	PCTPVST	DEG_SCF_FBW7_1	0.2222
p.P613L	SIDM00928	Breast Carcinoma	GDSC	PCTPVST	DEG_SCF_FBW7_1	0.2778
p.P613L	CAL-85-1	breast	COSMIC	PCTPVST	DEG_SCF_FBW7_1	0.2778
p.P612L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PCTPVST	DEG_SCF_FBW7_1	0.25
p.R614H	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PCTPVST	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6XZF7	Dynamin-binding protein	DEG_SCF_FBW7_1	615:621	PCTPVST	FBXW7	0.9277	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons