DegronMD

Uniprot ID: Q6XZF7

Source protein: Dynamin-binding protein

Source gene: DNMBP

Class: DEG_SCF_FBW7_2

Location: 226:232

E3 ligase: FBXW7

DEGRON score: 0.9314

ASA_SCORE: 82.3857

COIL: 0.8284

CONS_SCORE: 0.2529

DSS_SCORE: 0.7361

HELIX: 0.0323

FCONS_SCORE: 0.9946

RIG_SCORE: 0.7164

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y223C	DO26469	LUSC	ICGC	VDTPVGE	DEG_SCF_FBW7_2	0.25
p.Y223C	DO50118	STAD	ICGC	VDTPVGE	DEG_SCF_FBW7_2	0.25
p.S230N	DO219195	LUSC	ICGC	VDTPVGE	DEG_SCF_FBW7_2	0.7069
p.S236F	DO222875	MELA	ICGC	VDTPVGE	DEG_SCF_FBW7_2	0.2222
p.S236F	DO37991	SKCM	ICGC	VDTPVGE	DEG_SCF_FBW7_2	0.2222
p.I221V	SIDM00798	Rhabdomyosarcoma	GDSC	VDTPVGE	DEG_SCF_FBW7_2	0.1944
p.I221V	ACH-000201	Rhabdoid	CCLE	VDTPVGE	DEG_SCF_FBW7_2	0.1944
p.I221V	ACH-001212	Rhabdoid	CCLE	VDTPVGE	DEG_SCF_FBW7_2	0.1944
p.I221V	A204	soft_tissue	COSMIC	VDTPVGE	DEG_SCF_FBW7_2	0.1944
p.E241K	SIDM01059	Melanoma	GDSC	VDTPVGE	DEG_SCF_FBW7_2	0.0833
p.E241K	ACH-000915	Skin Cancer	CCLE	VDTPVGE	DEG_SCF_FBW7_2	0.0833
p.E241K	IPC-298	skin	COSMIC	VDTPVGE	DEG_SCF_FBW7_2	0.0833
p.N226D	K2	skin	COSMIC	VDTPVGE	DEG_SCF_FBW7_2	0.6932
p.R216C	AN3-CA	endometrium	COSMIC	VDTPVGE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6XZF7	Dynamin-binding protein	DEG_SCF_FBW7_2	226:232	VDTPVGE	FBXW7	0.9314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons