DegronMD

Uniprot ID: Q6XZF7

Source protein: Dynamin-binding protein

Source gene: DNMBP

Class: DEG_SPOP_SBC_1

Location: 618:622

E3 ligase: SPOP

DEGRON score: 0.911

ASA_SCORE: 85.56

COIL: 0.9494

CONS_SCORE: 0.2654

DSS_SCORE: 0.6936

HELIX: 0.0238

FCONS_SCORE: 0.9168

RIG_SCORE: 0.609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P623H	TCGA-A6-3809	COAD	TCGA	PVSTS	DEG_SPOP_SBC_1	0.3056
p.P623H	DO8722	COAD	ICGC	PVSTS	DEG_SPOP_SBC_1	0.3056
p.Q629H	TCGA-B5-A11E	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	0.1389
p.Q629H	DO41644	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.R614C	TCGA-C5-A1M8	CESC	TCGA	PVSTS	DEG_SPOP_SBC_1	0.2222
p.R614C	DO48993	CESC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.2222
p.P618L	TCGA-DD-AADG	LIHC	TCGA	PVSTS	DEG_SPOP_SBC_1	0.7582
p.P618L	DO219571	LIHC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.7582
p.P612A	DO223407	CLLE	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1667
p.F620L	DO8730	COAD	ICGC	PVSTS	DEG_SPOP_SBC_1	0.6981
p.P611L	DO233613	GACA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P611L	DO220906	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.T630I	DO220879	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1111
p.P611S	DO220906	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P623L	DO229502	SKCA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.3056
p.S611Y	DO41361	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P613L	SIDM00928	Breast Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	0.1944
p.P613L	CAL-85-1	breast	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.1944
p.P612L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	0.1667
p.R614H	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L390	Pleckstrin homology domain-containing family G member 3	DEG_SPOP_SBC_1	2:6	PVSTS	SPOP	0.7869	More...
O14836	Tumor necrosis factor receptor superfamily member 13B	DEG_SPOP_SBC_1	219:223	PVSTS	SPOP	0.8996	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	771:775	PVSTS	SPOP	0.9914	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	339:343	PVSTS	SPOP	0.933	More...
P07333	Macrophage colony-stimulating factor 1 receptor	DEG_SPOP_SBC_1	728:732	PVSTS	SPOP	0.9843	More...
P07947	Tyrosine-protein kinase Yes	DEG_SPOP_SBC_1	24:28	PVSTS	SPOP	0.9939	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	4012:4016	PVSTS	SPOP	0.5207	More...
Q06187	Tyrosine-protein kinase BTK	DEG_SPOP_SBC_1	210:214	PVSTS	SPOP	0.968	More...
Q13492	Phosphatidylinositol-binding clathrin assembly protein	DEG_SPOP_SBC_1	360:364	PVSTS	SPOP	0.9979	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	1654:1658	PVSTS	SPOP	0.91	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1095:1099	PVSTS	SPOP	0.9912	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	616:620	PVSTS	SPOP	0.991	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	618:622	PVSTS	SPOP	0.911	More...
Q8N3J3	Homologous recombination OB-fold protein	DEG_SPOP_SBC_1	103:107	PVSTS	SPOP	0.857	More...
Q8NFM4	Adenylate cyclase type 4	DEG_SPOP_SBC_1	500:504	PVSTS	SPOP	0.7358	More...
Q96JG6	Syndetin	DEG_SPOP_SBC_1	503:507	PVSTS	SPOP	0.9603	More...
Q8N8K9	Uncharacterized protein KIAA1958	DEG_SPOP_SBC_1	311:315	PVSTS	SPOP	0.9956	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	911:915	PVSTS	SPOP	0.8934	More...
A6NCI8	Uncharacterized protein C2orf78	DEG_SPOP_SBC_1	261:265	PVSTS	SPOP	0.9843	More...
Q2M3A8	Putative uncharacterized protein MRGPRG-AS1	DEG_SPOP_SBC_1	84:88	PVSTS	SPOP	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTS

Degron related mutations and impact score

Drug responses associated with DNMBP mutations

All proteins holding degron of PVSTS