DegronMD - Q8N3J3(HROB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S105F	SIDM00608	Plasma Cell Myeloma	GDSC	PVSTS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.7982
p.S574C	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	DSGDGS	DEG_SCF_TRCP1_1	576:581	Mutation rewiring degron network	0.2778
p.Y573C	SIDM00533	Pancreatic Carcinoma	GDSC	DSGDGS	DEG_SCF_TRCP1_1	576:581	Mutation rewiring degron network	0.25
p.V104A	SIDM01196	Hepatocellular Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.5825
p.R102K	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSTS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.3056
p.K584E	SIDM00241	Breast Carcinoma	GDSC	DSGDGS	DEG_SCF_TRCP1_1	576:581	Mutation blocking ubiquitination signal	0.6944
p.R92H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PASST	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons