DegronMD - Q13492(PICALM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M369L	TCGA-AP-A059	UCEC	TCGA	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation rewiring degron network	0.1389
p.M369L	TCGA-AP-A059	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1944
p.M369L	DO41361	UCEC	ICGC	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation rewiring degron network	0.1389
p.M369L	DO41361	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1944
p.A371V	TCGA-B5-A3FA	UCEC	TCGA	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation rewiring degron network	0.1944
p.A371V	TCGA-B5-A3FA	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1389
p.A371V	DO52402	UCEC	ICGC	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation rewiring degron network	0.1944
p.A371V	DO52402	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1389
p.A358S	TCGA-B5-A3FC	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.2778
p.A358S	DO41871	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.2778
p.P360S	TCGA-D9-A4Z3	SKCM	TCGA	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6752
p.P360S	DO47555	SKCM	ICGC	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6752
p.P360S	SIDM00217	Colorectal Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6752
p.P360S	ACH-000999	Colon/Colorectal Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6752
p.P360S	SNU-1040	large intestine	COSMIC	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6752
p.S378T	TCGA-VQ-A8PC	STAD	TCGA	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation altering degron motif	0.6005
p.S378T	DO51767	STAD	ICGC	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation altering degron motif	0.6005
p.H351Y	TCGA-XF-A9T3	BLCA	TCGA	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0833
p.H351Y	DO51922	BLCA	ICGC	PVSTS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0833
p.S381G	SIDM00780	Colorectal Carcinoma	GDSC	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation altering degron motif	0.6993
p.S381G	ACH-000967	Colon/Colorectal Cancer	CCLE	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation altering degron motif	0.6993
p.I376M	ACH-000272	Kidney Cancer	CCLE	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation altering degron motif	0.6507
p.L384P	KYSE-180	oesophagus	COSMIC	IFSTPSSS	DEG_SCF_FBW7_1	376:383	Mutation rewiring degron network	0.3056

Kaplan plot for PICALM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PICALM

UniProt ID: Q13492

Entrez ID: 8301

Protein name: Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PICALM in