DegronMD

Uniprot ID: Q13492

Source protein: Phosphatidylinositol-binding clathrin assembly protein

Source gene: PICALM

Class: DEG_SCF_FBW7_1

Location: 376:383

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 70.9625

COIL: 0.9244

CONS_SCORE: 0.2944

DSS_SCORE: 0.474

HELIX: 0.0418

FCONS_SCORE: 0.9875

RIG_SCORE: 0.6704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M369L	TCGA-AP-A059	UCEC	TCGA	IFSTPSSS	DEG_SCF_FBW7_1	0.1389
p.M369L	DO41361	UCEC	ICGC	IFSTPSSS	DEG_SCF_FBW7_1	0.1389
p.A371V	TCGA-B5-A3FA	UCEC	TCGA	IFSTPSSS	DEG_SCF_FBW7_1	0.1944
p.A371V	DO52402	UCEC	ICGC	IFSTPSSS	DEG_SCF_FBW7_1	0.1944
p.S378T	TCGA-VQ-A8PC	STAD	TCGA	IFSTPSSS	DEG_SCF_FBW7_1	0.6005
p.S378T	DO51767	STAD	ICGC	IFSTPSSS	DEG_SCF_FBW7_1	0.6005
p.S381G	SIDM00780	Colorectal Carcinoma	GDSC	IFSTPSSS	DEG_SCF_FBW7_1	0.6993
p.S381G	ACH-000967	Colon/Colorectal Cancer	CCLE	IFSTPSSS	DEG_SCF_FBW7_1	0.6993
p.I376M	ACH-000272	Kidney Cancer	CCLE	IFSTPSSS	DEG_SCF_FBW7_1	0.6507
p.L384P	KYSE-180	oesophagus	COSMIC	IFSTPSSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13492	Phosphatidylinositol-binding clathrin assembly protein	DEG_SCF_FBW7_1	376:383	IFSTPSSS	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons