DegronMD

Uniprot ID: P07333

Source protein: Macrophage colony-stimulating factor 1 receptor

Source gene: CSF1R

Class: DEG_SPOP_SBC_1

Location: 728:732

E3 ligase: SPOP

DEGRON score: 0.9843

ASA_SCORE: 80.32

COIL: 0.8772

CONS_SCORE: 0.4564

DSS_SCORE: 0.5257

HELIX: 0.0338

FCONS_SCORE: 1.0389

RIG_SCORE: 0.6559

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P728H	TCGA-AX-A1CE	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	0.7694
p.P728H	DO42280	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.7694
p.T731N	TCGA-55-7994	LUAD	TCGA	PVSTS	DEG_SPOP_SBC_1	0.7055
p.T731N	DO45311	LUAD	ICGC	PVSTS	DEG_SPOP_SBC_1	0.7055
p.T731S	DO229446	SKCA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.6005
p.R727K	ACH-001232	Brain Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	0.3056
p.M726I	TCGA-BT-A20T	BLCA	TCGA	PVSTS	DEG_SPOP_SBC_1	0.2778
p.M726I	DO804	BLCA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.2778
p.M726I	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	0.2778
p.M726I	H513	pleura	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.2778
p.M726V	DO232761	PBCA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.2778
p.E725D	DO233506	PRAD	ICGC	PVSTS	DEG_SPOP_SBC_1	0.25
p.D721N	DO222710	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.L742M	ACH-001441	Eye Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 14 of 14 entries

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Drug responses associated with CSF1R mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01007	ALL\|lymphoblastic_leukemia	p.E920D (No)	GDSC	Sunitinib	2.0565
SIDM01007	ALL\|lymphoblastic_leukemia	p.E920D (No)	GDSC	GW-2580	122.3043
SIDM01007	ALL\|lymphoblastic_leukemia	p.E920D (No)	GDSC	Pazopanib	9.0608
SIDM01007	ALL\|lymphoblastic_leukemia	p.E920D (No)	GDSC	Linifanib	4.2428
SIDM01007	ALL\|lymphoblastic_leukemia	p.S188P (No)	GDSC	Sunitinib	2.0565
SIDM01007	ALL\|lymphoblastic_leukemia	p.S188P (No)	GDSC	GW-2580	122.3043
SIDM01007	ALL\|lymphoblastic_leukemia	p.S188P (No)	GDSC	Pazopanib	9.0608
SIDM01007	ALL\|lymphoblastic_leukemia	p.S188P (No)	GDSC	Linifanib	4.2428
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V138I (No)	GDSC	Sunitinib	2.8236
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V138I (No)	GDSC	GW-2580	192.1361
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V138I (No)	GDSC	Pazopanib	27.7744
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V138I (No)	GDSC	Linifanib	9.659
SIDM00989	BLCA\|bladder	p.S937_S938insGS (No)	GDSC	GW-2580	131.6997
SIDM00989	BLCA\|bladder	p.S937_S938insGS (No)	GDSC	Pazopanib	27.8581
SIDM00989	BLCA\|bladder	p.S937_S938insGS (No)	GDSC	Linifanib	9.0538
SIDM00940	BRCA\|breast	p.R106Q (No)	GDSC	GW-2580	440.0921
SIDM00940	BRCA\|breast	p.R106Q (No)	GDSC	Pazopanib	20.2904
SIDM00940	BRCA\|breast	p.R106Q (No)	GDSC	Linifanib	21.8688
SIDM00630	BRCA\|breast	p.Q970* (No)	GDSC	GW-2580	150.6293
SIDM00630	BRCA\|breast	p.Q970* (No)	GDSC	Pazopanib	12.1881
SIDM00630	BRCA\|breast	p.Q970* (No)	GDSC	Linifanib	29.1021
SIDM00673	BRCA\|breast	p.P510A (No)	GDSC	GW-2580	288.5063
SIDM00673	BRCA\|breast	p.P510A (No)	GDSC	Pazopanib	19.2114
SIDM00673	BRCA\|breast	p.P510A (No)	GDSC	Linifanib	11.3311
SIDM00781	COREAD\|large_intestine	p.P402fs*3 (No)	GDSC	Sunitinib	64.3744

Showing 1 to 25 of 157 entries

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All proteins holding degron of PVSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFM4	Adenylate cyclase type 4	DEG_SPOP_SBC_1	500:504	PVSTS	SPOP	0.7358	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	616:620	PVSTS	SPOP	0.991	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	339:343	PVSTS	SPOP	0.933	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	618:622	PVSTS	SPOP	0.911	More...
Q8N3J3	Homologous recombination OB-fold protein	DEG_SPOP_SBC_1	103:107	PVSTS	SPOP	0.857	More...
P07333	Macrophage colony-stimulating factor 1 receptor	DEG_SPOP_SBC_1	728:732	PVSTS	SPOP	0.9843	More...
Q13492	Phosphatidylinositol-binding clathrin assembly protein	DEG_SPOP_SBC_1	360:364	PVSTS	SPOP	0.9979	More...
A1L390	Pleckstrin homology domain-containing family G member 3	DEG_SPOP_SBC_1	2:6	PVSTS	SPOP	0.7869	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	771:775	PVSTS	SPOP	0.9914	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1095:1099	PVSTS	SPOP	0.9912	More...
Q2M3A8	Putative uncharacterized protein MRGPRG-AS1	DEG_SPOP_SBC_1	84:88	PVSTS	SPOP	0.9694	More...
Q96JG6	Syndetin	DEG_SPOP_SBC_1	503:507	PVSTS	SPOP	0.9603	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	4012:4016	PVSTS	SPOP	0.5207	More...
O14836	Tumor necrosis factor receptor superfamily member 13B	DEG_SPOP_SBC_1	219:223	PVSTS	SPOP	0.8996	More...
Q06187	Tyrosine-protein kinase BTK	DEG_SPOP_SBC_1	210:214	PVSTS	SPOP	0.968	More...
P07947	Tyrosine-protein kinase Yes	DEG_SPOP_SBC_1	24:28	PVSTS	SPOP	0.9939	More...
A6NCI8	Uncharacterized protein C2orf78	DEG_SPOP_SBC_1	261:265	PVSTS	SPOP	0.9843	More...
Q8N8K9	Uncharacterized protein KIAA1958	DEG_SPOP_SBC_1	311:315	PVSTS	SPOP	0.9956	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	1654:1658	PVSTS	SPOP	0.91	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	911:915	PVSTS	SPOP	0.8934	More...

Showing 1 to 20 of 20 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTS

Degron related mutations and impact score

Drug responses associated with CSF1R mutations

All proteins holding degron of PVSTS