DegronMD

Uniprot ID: Q06187

Source protein: Tyrosine-protein kinase BTK

Source gene: BTK

Class: DEG_SPOP_SBC_1

Location: 210:214

E3 ligase: SPOP

DEGRON score: 0.968

ASA_SCORE: 85.44

COIL: 0.876

CONS_SCORE: 0.3815

DSS_SCORE: 0.3855

HELIX: 0.076

FCONS_SCORE: 0.8429

RIG_SCORE: 0.6879

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K218N	TCGA-BS-A0UF	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	0.3333
p.K218N	DO41488	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	0.3333
p.P203Q	DO228952	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P203Q	ACH-001526	Bone Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P203Q	HuO9	bone	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.L202I	DO229036	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1111
p.A221D	DO229009	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P221S	SIDM00057	Neuroblastoma	GDSC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P221S	ACN	autonomic_ganglia	COSMIC	PVSTS	DEG_SPOP_SBC_1	0.1389
p.P210K	ACH-000390	Lung Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	0.7312
p.P210T	ACH-000390	Lung Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	0.7031
p.T213I	ACH-000985	Colon/Colorectal Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	0.7078
p.P206Q	ACH-001091	Colon/Colorectal Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	0.2222

Drug responses associated with BTK mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V427M (No)	GDSC	LFM-A13	75.891
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V427M (No)	GDSC	QL-XII-47	6.5333
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V427M (No)	GDSC	QL-X-138	7.6242
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V427M (No)	GDSC	Ibrutinib	2.1824
SIDM00151	OV\|ovary	p.R46H (No)	GDSC	Ibrutinib	1.2713
SIDM00885	BRCA\|breast	p.D549A (No)	GDSC	LFM-A13	119.5988
SIDM00885	BRCA\|breast	p.D549A (No)	GDSC	QL-XII-47	6.6219
SIDM00885	BRCA\|breast	p.D549A (No)	GDSC	QL-X-138	6.7852
SIDM00885	BRCA\|breast	p.D549A (No)	GDSC	Ibrutinib	42.281
SIDM00683	PRAD\|prostate	p.Q290L (No)	GDSC	LFM-A13	64.7006
SIDM00683	PRAD\|prostate	p.Q290L (No)	GDSC	QL-XII-47	0.3473
SIDM00683	PRAD\|prostate	p.Q290L (No)	GDSC	QL-X-138	0.5024
SIDM00683	PRAD\|prostate	p.Q290L (No)	GDSC	QL-XII-61	51.0763
SIDM00683	PRAD\|prostate	p.Q290L (No)	GDSC	Ibrutinib	311.64
SIDM00956	ESCA\|oesophagus	p.K26N (No)	GDSC	LFM-A13	141.176
SIDM00956	ESCA\|oesophagus	p.K26N (No)	GDSC	QL-XII-47	1.6587
SIDM00956	ESCA\|oesophagus	p.K26N (No)	GDSC	QL-X-138	5.2736
SIDM00956	ESCA\|oesophagus	p.K26N (No)	GDSC	Ibrutinib	58.466
SIDM00666	LGG\|glioma	p.C464F (No)	GDSC	LFM-A13	72.2017
SIDM00666	LGG\|glioma	p.C464F (No)	GDSC	QL-XII-47	2.9839
SIDM00666	LGG\|glioma	p.C464F (No)	GDSC	QL-X-138	5.6265
SIDM00666	LGG\|glioma	p.C464F (No)	GDSC	QL-XII-61	112.3062
SIDM01088	UNCLASSIFIED\|endometrium	p.M489I (No)	GDSC	QL-XII-47	40.9611
SIDM01088	UNCLASSIFIED\|endometrium	p.M489I (No)	GDSC	QL-X-138	29.1969
SIDM01088	UNCLASSIFIED\|endometrium	p.M489I (No)	GDSC	QL-XII-61	19.1111
SIDM01088	UNCLASSIFIED\|endometrium	p.M489I (No)	GDSC	Ibrutinib	58.847
SIDM00220	OV\|ovary	p.W588C (No)	GDSC	LFM-A13	72.5145
SIDM00220	OV\|ovary	p.W588C (No)	GDSC	QL-XII-47	1.0948
SIDM00220	OV\|ovary	p.W588C (No)	GDSC	QL-X-138	0.8635
SIDM00220	OV\|ovary	p.W588C (No)	GDSC	QL-XII-61	36.7846
SIDM01030	ESCA\|oesophagus	p.R82K (No)	GDSC	LFM-A13	21.5201
SIDM01030	ESCA\|oesophagus	p.R82K (No)	GDSC	QL-XII-47	2.5901
SIDM01030	ESCA\|oesophagus	p.R82K (No)	GDSC	QL-X-138	6.0994
SIDM01030	ESCA\|oesophagus	p.R82K (No)	GDSC	Ibrutinib	9.329
SIDM00938	BRCA\|breast	p.Q379* (No)	GDSC	LFM-A13	101.236
SIDM00938	BRCA\|breast	p.Q379* (No)	GDSC	QL-XII-47	16.8256
SIDM00938	BRCA\|breast	p.Q379* (No)	GDSC	QL-X-138	2.4701
SIDM00415	UNCLASSIFIED\|B_cell_leukemia	p.I264N (No)	GDSC	LFM-A13	275.1546
SIDM00415	UNCLASSIFIED\|B_cell_leukemia	p.I264N (No)	GDSC	QL-XII-47	28.3568
SIDM00415	UNCLASSIFIED\|B_cell_leukemia	p.I264N (No)	GDSC	QL-X-138	8.79
SIDM01228	SKCM\|melanoma	p.E301fs*30 (No)	GDSC	LFM-A13	126.5575
SIDM01228	SKCM\|melanoma	p.E301fs*30 (No)	GDSC	QL-XII-47	1.4336
SIDM01228	SKCM\|melanoma	p.E301fs*30 (No)	GDSC	QL-X-138	0.6478
SIDM01228	SKCM\|melanoma	p.E301fs*30 (No)	GDSC	Ibrutinib	12.218
SIDM00498	COREAD\|large_intestine	p.Y361C (No)	GDSC	QL-XII-47	11.688
SIDM00498	COREAD\|large_intestine	p.Y361C (No)	GDSC	QL-X-138	14.3218
SIDM00498	COREAD\|large_intestine	p.Y361C (No)	GDSC	QL-XII-61	48.9492
SIDM00498	COREAD\|large_intestine	p.Y361C (No)	GDSC	Ibrutinib	558.89
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.L244* (No)	GDSC	QL-XII-61	300.3147
SIDM00946	ALL\|T_cell_leukemia	p.M596L (No)	GDSC	LFM-A13	23.777
SIDM00946	ALL\|T_cell_leukemia	p.M596L (No)	GDSC	QL-XII-47	1.2596
SIDM00946	ALL\|T_cell_leukemia	p.M596L (No)	GDSC	QL-X-138	0.5586
SIDM00946	ALL\|T_cell_leukemia	p.M596L (No)	GDSC	QL-XII-61	6.0966
SIDM00946	ALL\|T_cell_leukemia	p.M596L (No)	GDSC	Ibrutinib	80.255
SIDM00864	CESC\|cervix	p.K503R (No)	GDSC	LFM-A13	50.5788
SIDM00864	CESC\|cervix	p.K503R (No)	GDSC	QL-XII-47	3.8498
SIDM00864	CESC\|cervix	p.K503R (No)	GDSC	QL-X-138	7.561
SIDM00864	CESC\|cervix	p.K503R (No)	GDSC	QL-XII-61	8.7106
SIDM00864	CESC\|cervix	p.K503R (No)	GDSC	Ibrutinib	1.3492
SIDM00401	SKCM\|melanoma	p.P74L (No)	GDSC	LFM-A13	105.1266
SIDM00401	SKCM\|melanoma	p.P74L (No)	GDSC	QL-XII-47	6.1742
SIDM00401	SKCM\|melanoma	p.P74L (No)	GDSC	QL-X-138	171.3793
SIDM00401	SKCM\|melanoma	p.P74L (No)	GDSC	QL-XII-61	198.5599
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.P203Q (Yes)	GDSC	LFM-A13	231.9955
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.P203Q (Yes)	GDSC	QL-XII-47	10.7662
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.P203Q (Yes)	GDSC	QL-X-138	4.4146
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.P203Q (Yes)	GDSC	QL-XII-61	72.6998
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.P203Q (Yes)	GDSC	Ibrutinib	54.248
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.E439* (No)	GDSC	LFM-A13	122.833
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.E439* (No)	GDSC	QL-XII-47	3.0187
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.E439* (No)	GDSC	QL-X-138	3.6612
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.E439* (No)	GDSC	QL-XII-61	33.3829
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.E439* (No)	GDSC	Ibrutinib	302.24
SIDM00567	MB\|medulloblastoma	p.T495S (No)	GDSC	LFM-A13	138.681
SIDM00567	MB\|medulloblastoma	p.T495S (No)	GDSC	QL-XII-47	0.7825
SIDM00567	MB\|medulloblastoma	p.T495S (No)	GDSC	QL-X-138	0.2598
SIDM00567	MB\|medulloblastoma	p.T495S (No)	GDSC	QL-XII-61	114.838
SIDM00567	MB\|medulloblastoma	p.T495S (No)	GDSC	Ibrutinib	301.03
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G47R (No)	GDSC	LFM-A13	351.376
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G47R (No)	GDSC	QL-XII-47	9.5155
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G47R (No)	GDSC	QL-X-138	5.3271
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G47R (No)	GDSC	Ibrutinib	24.075
SIDM00995	UNCLASSIFIED\|skin_other	p.I197M (No)	GDSC	LFM-A13	45.1239
SIDM00995	UNCLASSIFIED\|skin_other	p.I197M (No)	GDSC	QL-XII-47	0.5781
SIDM00995	UNCLASSIFIED\|skin_other	p.I197M (No)	GDSC	QL-X-138	2.956
SIDM00336	SKCM\|melanoma	p.E589D (No)	GDSC	LFM-A13	175.1851
SIDM00336	SKCM\|melanoma	p.E589D (No)	GDSC	QL-XII-47	1.9518
SIDM00336	SKCM\|melanoma	p.E589D (No)	GDSC	QL-X-138	55.5597
SIDM00336	SKCM\|melanoma	p.E589D (No)	GDSC	Ibrutinib	284.31
SIDM00487	COREAD\|large_intestine	p.V113I (No)	GDSC	LFM-A13	184.1622
SIDM00487	COREAD\|large_intestine	p.V113I (No)	GDSC	QL-XII-47	1.5108
SIDM00487	COREAD\|large_intestine	p.V113I (No)	GDSC	QL-X-138	12.4542
SIDM00487	COREAD\|large_intestine	p.V113I (No)	GDSC	QL-XII-61	85.3452
SIDM00487	COREAD\|large_intestine	p.V113I (No)	GDSC	Ibrutinib	5.8332
SIDM00448	DLBC\|B_cell_lymphoma	p.I132N (No)	GDSC	LFM-A13	167.2201
SIDM00448	DLBC\|B_cell_lymphoma	p.I132N (No)	GDSC	QL-XII-47	7.3161
SIDM00448	DLBC\|B_cell_lymphoma	p.I132N (No)	GDSC	QL-X-138	14.44
SIDM00448	DLBC\|B_cell_lymphoma	p.I132N (No)	GDSC	QL-XII-61	94.8129
SIDM00448	DLBC\|B_cell_lymphoma	p.I132N (No)	GDSC	Ibrutinib	129.38
SIDM00225	SKCM\|melanoma	p.V105L (No)	GDSC	LFM-A13	57.2956
SIDM00225	SKCM\|melanoma	p.V105L (No)	GDSC	QL-XII-47	5.5078
SIDM00225	SKCM\|melanoma	p.V105L (No)	GDSC	QL-X-138	116.1461
SIDM00225	SKCM\|melanoma	p.V105L (No)	GDSC	QL-XII-61	5.5507
SIDM00360	UNCLASSIFIED\|pancreas	p.H143Y (No)	GDSC	QL-XII-47	18.0954
SIDM00360	UNCLASSIFIED\|pancreas	p.H143Y (No)	GDSC	QL-X-138	4.1466
SIDM00360	UNCLASSIFIED\|pancreas	p.H143Y (No)	GDSC	QL-XII-61	403.0856
SIDM00360	UNCLASSIFIED\|pancreas	p.H143Y (No)	GDSC	Ibrutinib	1141.7
SIDM01017	UNCLASSIFIED\|B_cell_leukemia	p.R255P (No)	GDSC	LFM-A13	14.2041
SIDM01017	UNCLASSIFIED\|B_cell_leukemia	p.R255P (No)	GDSC	QL-X-138	0.0933
SIDM01017	UNCLASSIFIED\|B_cell_leukemia	p.R255P (No)	GDSC	Ibrutinib	44.01
SIDM00684	GBM\|glioma	p.E240D (No)	GDSC	LFM-A13	143.6384
SIDM00684	GBM\|glioma	p.E240D (No)	GDSC	QL-XII-47	16.6054
SIDM00684	GBM\|glioma	p.E240D (No)	GDSC	QL-X-138	13.1309
SIDM00684	GBM\|glioma	p.E240D (No)	GDSC	Ibrutinib	101.91
SIDM01027	ESCA\|oesophagus	p.I470S (No)	GDSC	LFM-A13	159.9141
SIDM01027	ESCA\|oesophagus	p.I470S (No)	GDSC	QL-XII-47	0.4218
SIDM01027	ESCA\|oesophagus	p.I470S (No)	GDSC	QL-X-138	1.0228
SIDM01027	ESCA\|oesophagus	p.I470S (No)	GDSC	QL-XII-61	70.5224
SIDM01027	ESCA\|oesophagus	p.I470S (No)	GDSC	Ibrutinib	17.127
SIDM01040	OV\|ovary	p.P566L (No)	GDSC	LFM-A13	44.1095
SIDM01040	OV\|ovary	p.P566L (No)	GDSC	QL-XII-47	9.5112
SIDM01040	OV\|ovary	p.P566L (No)	GDSC	QL-X-138	2.3619
SIDM00238	OV\|ovary	p.L29M (No)	GDSC	QL-XII-47	3.4695
SIDM00238	OV\|ovary	p.L29M (No)	GDSC	QL-X-138	50.2496
SIDM00238	OV\|ovary	p.L29M (No)	GDSC	QL-XII-61	13.4704
SIDM00238	OV\|ovary	p.L29M (No)	GDSC	Ibrutinib	388.8

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L390	Pleckstrin homology domain-containing family G member 3	DEG_SPOP_SBC_1	2:6	PVSTS	SPOP	0.7869	More...
O14836	Tumor necrosis factor receptor superfamily member 13B	DEG_SPOP_SBC_1	219:223	PVSTS	SPOP	0.8996	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	771:775	PVSTS	SPOP	0.9914	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	339:343	PVSTS	SPOP	0.933	More...
P07333	Macrophage colony-stimulating factor 1 receptor	DEG_SPOP_SBC_1	728:732	PVSTS	SPOP	0.9843	More...
P07947	Tyrosine-protein kinase Yes	DEG_SPOP_SBC_1	24:28	PVSTS	SPOP	0.9939	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	4012:4016	PVSTS	SPOP	0.5207	More...
Q06187	Tyrosine-protein kinase BTK	DEG_SPOP_SBC_1	210:214	PVSTS	SPOP	0.968	More...
Q13492	Phosphatidylinositol-binding clathrin assembly protein	DEG_SPOP_SBC_1	360:364	PVSTS	SPOP	0.9979	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	1654:1658	PVSTS	SPOP	0.91	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1095:1099	PVSTS	SPOP	0.9912	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	616:620	PVSTS	SPOP	0.991	More...
Q6XZF7	Dynamin-binding protein	DEG_SPOP_SBC_1	618:622	PVSTS	SPOP	0.911	More...
Q8N3J3	Homologous recombination OB-fold protein	DEG_SPOP_SBC_1	103:107	PVSTS	SPOP	0.857	More...
Q8NFM4	Adenylate cyclase type 4	DEG_SPOP_SBC_1	500:504	PVSTS	SPOP	0.7358	More...
Q96JG6	Syndetin	DEG_SPOP_SBC_1	503:507	PVSTS	SPOP	0.9603	More...
Q8N8K9	Uncharacterized protein KIAA1958	DEG_SPOP_SBC_1	311:315	PVSTS	SPOP	0.9956	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	911:915	PVSTS	SPOP	0.8934	More...
A6NCI8	Uncharacterized protein C2orf78	DEG_SPOP_SBC_1	261:265	PVSTS	SPOP	0.9843	More...
Q2M3A8	Putative uncharacterized protein MRGPRG-AS1	DEG_SPOP_SBC_1	84:88	PVSTS	SPOP	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTS

Degron related mutations and impact score

Drug responses associated with BTK mutations

All proteins holding degron of PVSTS