DegronMD

Uniprot ID: Q6XZF7

Source protein: Dynamin-binding protein

Source gene: DNMBP

Class: DEG_APCC_DBOX_1

Location: 1259:1267

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9403

ASA_SCORE: 83.8778

COIL: 0.8534

CONS_SCORE: 0.2781

DSS_SCORE: 0.3976

HELIX: 0.0703

FCONS_SCORE: 0.9501

RIG_SCORE: 0.7352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1277W	TCGA-AA-A010	COAD	TCGA	ARKPLLGLP	DEG_APCC_DBOX_1	0.0556
p.L1266M	DO233898	GACA	ICGC	ARKPLLGLP	DEG_APCC_DBOX_1	0.5999
p.P1267T	DO228976	LICA	ICGC	ARKPLLGLP	DEG_APCC_DBOX_1	0.5919
p.P1267T	DO229015	LICA	ICGC	ARKPLLGLP	DEG_APCC_DBOX_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6XZF7	Dynamin-binding protein	DEG_APCC_DBOX_1	1259:1267	ARKPLLGLP	APC,CDC20,FZR1	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons