DegronMD - Q8NHH9(ATL2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S34L	TCGA-4Z-AA84	BLCA	TCGA	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7667
p.S34L	DO218988	BLCA	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7667
p.S27R	TCGA-51-4079	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation blocking phosphorylation signal	0.6111
p.S27R	DO26437	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation blocking phosphorylation signal	0.6111
p.P26Q	TCGA-EE-A2GT	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.P26Q	DO37946	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.E35Q	DO761	BLCA	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.6744
p.L47V	DO2401	BRCA	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.P42L	DO228422	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1944
p.P40Q	DO228976	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.25
p.Q44K	DO229027	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.L47F	DO23666	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.K38R	DO228177	PBCA	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation blocking phosphorylation signal	0.75
p.S38P	DO229218	THCA	ICGC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation blocking phosphorylation signal	0.75
p.V33I	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7076
p.V33I	ACH-000795	Leukemia	CCLE	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7076
p.V33I	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7076
p.N42D	SIDM00845	Burkitt's Lymphoma	GDSC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1944
p.D47G	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.D47G	ACH-000438	Lung Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.D47G	LU-65	lung	COSMIC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.T37A	SIDM01045	Endometrial Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7139
p.T37A	ACH-000978	Endometrial/Uterine Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7139
p.T37A	EN	endometrium	COSMIC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7139
p.D29G	LU-65	lung	COSMIC	VSSTT	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2222

Kaplan plot for ATL2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATL2

UniProt ID: Q8NHH9

Entrez ID: 64225

Protein name: Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ATL2 in