DegronMD - Q96K83(ZNF521)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G350V	TCGA-05-4382	LUAD	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2222
p.G350V	DO24900	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2222
p.L1173M	TCGA-13-0886	OV	TCGA	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.5999
p.L1173M	DO30250	OV	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.5999
p.L363F	TCGA-22-4599	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1944
p.L363F	TCGA-22-4599	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2778
p.L363F	DO26945	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1944
p.L363F	DO26945	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2778
p.N1169K	TCGA-28-1760	GBM	TCGA	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2222
p.N1169K	DO13725	GBM	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2222
p.K379N	TCGA-34-5231	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	365:369	Mutation substituting flanking lysine	0.1667
p.K379N	DO26772	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	365:369	Mutation substituting flanking lysine	0.1667
p.M370L	TCGA-55-5899	LUAD	TCGA	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.M370L	DO26042	LUAD	ICGC	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.V347A	TCGA-55-7227	LUAD	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.V347A	DO24050	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.T357M	TCGA-63-A5M9	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.T357M	TCGA-86-8358	LUAD	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.T357M	TCGA-SW-A7EB	STAD	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.T357M	DO25471	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.T357M	DO223726	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.T357M	DO50143	STAD	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.T357M	SIDM01151	Hepatocellular Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.T357M	ACH-000483	Liver Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.T357M	SNU-182	liver	COSMIC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7423
p.L363V	TCGA-75-6211	LUAD	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1944
p.L363V	TCGA-75-6211	LUAD	TCGA	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2778
p.L363V	DO25173	LUAD	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1944
p.L363V	DO25173	LUAD	ICGC	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.2778
p.S1170N	TCGA-AA-A01R	COAD	TCGA	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.S1170N	DO7934	COAD	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.R1183K	TCGA-AC-A23H	BRCA	TCGA	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2222
p.R1183K	DO2401	BRCA	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.2222
p.I1184T	TCGA-AJ-A23O	UCEC	TCGA	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1944
p.I1184T	DO43290	UCEC	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1944
p.S1185N	TCGA-B5-A11E	UCEC	TCGA	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation blocking phosphorylation signal	0.6111
p.S1185N	DO41644	UCEC	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation blocking phosphorylation signal	0.6111
p.Q1188R	TCGA-BR-8078	STAD	TCGA	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.0833
p.Q1188R	DO38288	STAD	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.0833
p.M370I	TCGA-CV-7568	HNSC	TCGA	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.M370I	DO14160	HNSC	ICGC	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.3056
p.S353F	TCGA-CV-7568	HNSC	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.3056
p.S353F	DO14160	HNSC	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.3056
p.V354M	TCGA-IB-7651	PAAD	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7208
p.V354M	TCGA-VS-A9UI	CESC	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7208
p.V354M	DO219734	CESC	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7208
p.V354M	DO46657	PAAD	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7208
p.V354M	SIDM00510	Small Cell Lung Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7208
p.V354M	ACH-002095	Lung Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7208
p.V354M	COR-L303	lung	COSMIC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7208
p.T348R	TCGA-VQ-A8DZ	STAD	TCGA	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1667
p.T348R	DO51755	STAD	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1667
p.T1175M	TCGA-XK-AAJP	PRAD	TCGA	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.7423
p.T1175M	DO233941	GACA	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.7423
p.T1175M	DO51410	PRAD	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation altering degron motif	0.7423
p.S1189L	DO234425	ESAD	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.0556
p.T348M	DO217822	GACA	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1667
p.Y351H	DO228416	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.25
p.V365M	DO230918	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7208
p.V365M	DO224546	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7208
p.L1164F	DO232761	PBCA	ICGC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.0833
p.S1170G	SIDM00776	Colorectal Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.S1170G	SIDM00782	Colorectal Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.S1170G	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.S1170R	SIDM01162	Kidney Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.S1170R	ACH-001398	Kidney Cancer	CCLE	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.S1170R	SW156	kidney	COSMIC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.25
p.V1165M	SIDM00068	Colorectal Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1111
p.V1165M	GEO	large intestine	COSMIC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1111
p.I1184M	SIDM00622	Glioblastoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1944
p.I1184M	D-247MG	central nervous system	COSMIC	LKTPQVS	DEG_SCF_FBW7_1	1173:1179	Mutation rewiring degron network	0.1944
p.V365L	ACH-001853	Bile Duct Cancer	CCLE	VDSST	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.6765
p.Y374H	GP5d	large intestine	COSMIC	VDSST	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1944
p.P349S	SW684	soft tissue	COSMIC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1944
p.N347D	WM793B	skin	COSMIC	VSSTT	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF521

UniProt ID: Q96K83

Entrez ID: 25925

Protein name: Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF521 in