DegronMD

Uniprot ID: Q96K83

Source protein: Zinc finger protein 521

Source gene: ZNF521

Class: DEG_SPOP_SBC_1

Location: 365:369

E3 ligase: SPOP

DEGRON score: 0.5207

ASA_SCORE: 60.64

COIL: 0.301

CONS_SCORE: 0.3277

DSS_SCORE: 0.6108

HELIX: 0.143

FCONS_SCORE: 0.9001

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L363F	TCGA-22-4599	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	0.2778
p.L363F	DO26945	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	0.2778
p.K379N	TCGA-34-5231	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	0.1667
p.K379N	DO26772	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	0.1667
p.M370L	TCGA-55-5899	LUAD	TCGA	VDSST	DEG_SPOP_SBC_1	0.3056
p.M370L	DO26042	LUAD	ICGC	VDSST	DEG_SPOP_SBC_1	0.3056
p.L363V	TCGA-75-6211	LUAD	TCGA	VDSST	DEG_SPOP_SBC_1	0.2778
p.L363V	DO25173	LUAD	ICGC	VDSST	DEG_SPOP_SBC_1	0.2778
p.M370I	TCGA-CV-7568	HNSC	TCGA	VDSST	DEG_SPOP_SBC_1	0.3056
p.M370I	DO14160	HNSC	ICGC	VDSST	DEG_SPOP_SBC_1	0.3056
p.V365M	DO230918	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	0.7208
p.V365M	DO224546	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	0.7208
p.V365L	ACH-001853	Bile Duct Cancer	CCLE	VDSST	DEG_SPOP_SBC_1	0.6765
p.Y374H	GP5d	large_intestine	COSMIC	VDSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13615	Myotubularin-related protein 3	DEG_SPOP_SBC_1	842:846	VDSST	SPOP	0.9926	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	2335:2339	VDSST	SPOP	0.9382	More...
Q92619	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1	DEG_SPOP_SBC_1	226:230	VDSST	SPOP	0.9874	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	365:369	VDSST	SPOP	0.5207	More...
Q9BQE9	B-cell CLL/lymphoma 7 protein family member B	DEG_SPOP_SBC_1	105:109	VDSST	SPOP	0.9379	More...
Q6IEE7	Transmembrane protein 132E	DEG_SPOP_SBC_1	643:647	VDSST	SPOP	0.8527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons