DegronMD - Q13615(MTMR3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E836K	TCGA-18-5595	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1667
p.R838G	TCGA-85-6561	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.2222
p.R1032C	TCGA-A5-A0G1	UCEC	TCGA	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.1389
p.R1032C	TCGA-DU-6392	LGG	TCGA	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.1389
p.L1031M	TCGA-AP-A051	UCEC	TCGA	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.1667
p.R1030C	TCGA-BR-8487	STAD	TCGA	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.1944
p.V842M	TCGA-L5-A4OW	ESCA	TCGA	VDSST	DEG_SPOP_SBC_1	842:846	Mutation altering degron motif	0.7208
p.R836C	DO51948	BLCA	ICGC	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1667
p.R836C	DO37421	SKCM	ICGC	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1667
p.R836C	DO41644	UCEC	ICGC	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1667
p.H728Y	DO219095	BLCA	ICGC	IGLHQD	LIG_APCC_ABBA_1	737:742	Mutation rewiring degron network	0.0833
p.V1034L	DO1249	BRCA	ICGC	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.0833
p.R836H	DO8842	COAD	ICGC	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1667
p.S839F	DO233088	GACA	ICGC	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.25
p.P748L	DO48665	SKCM	ICGC	IGLHQD	LIG_APCC_ABBA_1	737:742	Mutation rewiring degron network	0.1667
p.P748H	DO38165	SKCM	ICGC	IGLHQD	LIG_APCC_ABBA_1	737:742	Mutation rewiring degron network	0.1667
p.F1029I	DO229275	THCA	ICGC	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.2222
p.Q742H	DO229275	THCA	ICGC	IGLHQD	LIG_APCC_ABBA_1	737:742	Mutation altering degron motif	0.7582
p.C1017Y	DO229208	THCA	ICGC	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.25
p.Q1026H	DO52402	UCEC	ICGC	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.3056
p.S835R	DO42568	UCEC	ICGC	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.1389
p.D832V	DO41392	UCEC	ICGC	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.0556
p.T1026M	SIDM00480	Ovarian Carcinoma	GDSC	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.3056
p.T1026M	OAW-42	ovary	COSMIC	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.3056
p.S727N	SIDM01451	Pancreatic Carcinoma	GDSC	IGLHQD	LIG_APCC_ABBA_1	737:742	Mutation rewiring degron network	0.0556
p.H855Y	ACH-000127	Bladder Cancer	CCLE	VDSST	DEG_SPOP_SBC_1	842:846	Mutation substituting flanking lysine	0.1944
p.M841V	ACH-000964	Leukemia	CCLE	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.3056
p.A840V	ACH-000984	Endometrial/Uterine Cancer	CCLE	VDSST	DEG_SPOP_SBC_1	842:846	Mutation rewiring degron network	0.2778
p.Q1019H	ACH-002337	Lung Cancer	CCLE	MSVYTD	LIG_APCC_ABBA_1	1020:1025	Mutation rewiring degron network	0.3056

Kaplan plot for MTMR3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTMR3

UniProt ID: Q13615

Entrez ID: 8897

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTMR3 in