DegronMD

Uniprot ID: Q13615

Source protein: Myotubularin-related protein 3

Source gene: MTMR3

Class: LIG_APCC_ABBA_1

Location: 1020:1025

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9893

ASA_SCORE: 57.8667

COIL: 0.7452

CONS_SCORE: 0.3865

DSS_SCORE: 0.5614

HELIX: 0.0493

FCONS_SCORE: 1.1119

RIG_SCORE: 0.7259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1032C	TCGA-A5-A0G1	UCEC	TCGA	MSVYTD	LIG_APCC_ABBA_1	0.1389
p.R1032C	TCGA-DU-6392	LGG	TCGA	MSVYTD	LIG_APCC_ABBA_1	0.1389
p.L1031M	TCGA-AP-A051	UCEC	TCGA	MSVYTD	LIG_APCC_ABBA_1	0.1667
p.R1030C	TCGA-BR-8487	STAD	TCGA	MSVYTD	LIG_APCC_ABBA_1	0.1944
p.V1034L	DO1249	BRCA	ICGC	MSVYTD	LIG_APCC_ABBA_1	0.0833
p.F1029I	DO229275	THCA	ICGC	MSVYTD	LIG_APCC_ABBA_1	0.2222
p.C1017Y	DO229208	THCA	ICGC	MSVYTD	LIG_APCC_ABBA_1	0.25
p.Q1026H	DO52402	UCEC	ICGC	MSVYTD	LIG_APCC_ABBA_1	0.3056
p.T1026M	SIDM00480	Ovarian Carcinoma	GDSC	MSVYTD	LIG_APCC_ABBA_1	0.3056
p.T1026M	OAW-42	ovary	COSMIC	MSVYTD	LIG_APCC_ABBA_1	0.3056
p.Q1019H	ACH-002337	Lung Cancer	CCLE	MSVYTD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13615	Myotubularin-related protein 3	LIG_APCC_ABBA_1	1020:1025	MSVYTD	APC,CDC20,FZR1	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons