DegronMD

Uniprot ID: Q13615

Source protein: Myotubularin-related protein 3

Source gene: MTMR3

Class: DEG_SPOP_SBC_1

Location: 842:846

E3 ligase: SPOP

DEGRON score: 0.9926

ASA_SCORE: 74.94

COIL: 0.8004

CONS_SCORE: 0.3069

DSS_SCORE: 0.564

HELIX: 0.1586

FCONS_SCORE: 1.0436

RIG_SCORE: 0.6993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E836K	TCGA-18-5595	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	0.1667
p.R838G	TCGA-85-6561	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	0.2222
p.V842M	TCGA-L5-A4OW	ESCA	TCGA	VDSST	DEG_SPOP_SBC_1	0.7208
p.R836C	DO51948	BLCA	ICGC	VDSST	DEG_SPOP_SBC_1	0.1667
p.R836C	DO37421	SKCM	ICGC	VDSST	DEG_SPOP_SBC_1	0.1667
p.R836C	DO41644	UCEC	ICGC	VDSST	DEG_SPOP_SBC_1	0.1667
p.R836H	DO8842	COAD	ICGC	VDSST	DEG_SPOP_SBC_1	0.1667
p.S839F	DO233088	GACA	ICGC	VDSST	DEG_SPOP_SBC_1	0.25
p.S835R	DO42568	UCEC	ICGC	VDSST	DEG_SPOP_SBC_1	0.1389
p.D832V	DO41392	UCEC	ICGC	VDSST	DEG_SPOP_SBC_1	0.0556
p.H855Y	ACH-000127	Bladder Cancer	CCLE	VDSST	DEG_SPOP_SBC_1	0.1944
p.M841V	ACH-000964	Leukemia	CCLE	VDSST	DEG_SPOP_SBC_1	0.3056
p.A840V	ACH-000984	Endometrial/Uterine Cancer	CCLE	VDSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13615	Myotubularin-related protein 3	DEG_SPOP_SBC_1	842:846	VDSST	SPOP	0.9926	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	2335:2339	VDSST	SPOP	0.9382	More...
Q92619	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1	DEG_SPOP_SBC_1	226:230	VDSST	SPOP	0.9874	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	365:369	VDSST	SPOP	0.5207	More...
Q9BQE9	B-cell CLL/lymphoma 7 protein family member B	DEG_SPOP_SBC_1	105:109	VDSST	SPOP	0.9379	More...
Q6IEE7	Transmembrane protein 132E	DEG_SPOP_SBC_1	643:647	VDSST	SPOP	0.8527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons