DegronMD - Q6IEE7(TMEM132E)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y643C	TCGA-17-Z050	LUAD	TCGA	VDSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7087
p.S642C	TCGA-85-8479	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.S642C	DO45443	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.P656S	TCGA-90-A4EE	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0833
p.P656S	DO45513	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0833
p.S642P	TCGA-AA-3949	COAD	TCGA	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.S642P	DO7798	COAD	ICGC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.G646D	TCGA-B7-5816	STAD	TCGA	VDSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7198
p.G646D	DO38599	STAD	ICGC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7198
p.L636I	TCGA-NJ-A4YQ	LUAD	TCGA	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.L636I	DO218944	LUAD	ICGC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.D636N	SIDM00282	Colorectal Carcinoma	GDSC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.D636N	SIDM00965	Small Cell Lung Carcinoma	GDSC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.D636N	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.D636N	HCE-4	oesophagus	COSMIC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.D636N	CW-2	large intestine	COSMIC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.D636N	NCI-H446	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.L651H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VDSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222

Kaplan plot for TMEM132E in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM132E

UniProt ID: Q6IEE7

Entrez ID: 124842

Protein name: Transmembrane protein 132E

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM132E in