DegronMD

Uniprot ID: Q6IEE7

Source protein: Transmembrane protein 132E

Source gene: TMEM132E

Class: DEG_SPOP_SBC_1

Location: 643:647

E3 ligase: SPOP

DEGRON score: 0.8527

ASA_SCORE: 62.78

COIL: 0.589

CONS_SCORE: 0.8565

DSS_SCORE: 0.4085

HELIX: 0.025

FCONS_SCORE: 1.0876

RIG_SCORE: 0.7754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y643C	TCGA-17-Z050	LUAD	TCGA	VDSST	DEG_SPOP_SBC_1	0.7087
p.S642C	TCGA-85-8479	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	0.3056
p.S642C	DO45443	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	0.3056
p.P656S	TCGA-90-A4EE	LUSC	TCGA	VDSST	DEG_SPOP_SBC_1	0.0833
p.P656S	DO45513	LUSC	ICGC	VDSST	DEG_SPOP_SBC_1	0.0833
p.S642P	TCGA-AA-3949	COAD	TCGA	VDSST	DEG_SPOP_SBC_1	0.3056
p.S642P	DO7798	COAD	ICGC	VDSST	DEG_SPOP_SBC_1	0.3056
p.G646D	TCGA-B7-5816	STAD	TCGA	VDSST	DEG_SPOP_SBC_1	0.7198
p.G646D	DO38599	STAD	ICGC	VDSST	DEG_SPOP_SBC_1	0.7198
p.L636I	TCGA-NJ-A4YQ	LUAD	TCGA	VDSST	DEG_SPOP_SBC_1	0.1389
p.L636I	DO218944	LUAD	ICGC	VDSST	DEG_SPOP_SBC_1	0.1389
p.D636N	SIDM00282	Colorectal Carcinoma	GDSC	VDSST	DEG_SPOP_SBC_1	0.1389
p.D636N	SIDM00965	Small Cell Lung Carcinoma	GDSC	VDSST	DEG_SPOP_SBC_1	0.1389
p.D636N	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VDSST	DEG_SPOP_SBC_1	0.1389
p.D636N	HCE-4	oesophagus	COSMIC	VDSST	DEG_SPOP_SBC_1	0.1389
p.D636N	CW-2	large_intestine	COSMIC	VDSST	DEG_SPOP_SBC_1	0.1389
p.D636N	NCI-H446	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	0.1389
p.L651H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VDSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13615	Myotubularin-related protein 3	DEG_SPOP_SBC_1	842:846	VDSST	SPOP	0.9926	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	2335:2339	VDSST	SPOP	0.9382	More...
Q92619	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1	DEG_SPOP_SBC_1	226:230	VDSST	SPOP	0.9874	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	365:369	VDSST	SPOP	0.5207	More...
Q9BQE9	B-cell CLL/lymphoma 7 protein family member B	DEG_SPOP_SBC_1	105:109	VDSST	SPOP	0.9379	More...
Q6IEE7	Transmembrane protein 132E	DEG_SPOP_SBC_1	643:647	VDSST	SPOP	0.8527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons