DegronMD

Uniprot ID: Q92619

Source protein: Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1

Source gene: ARHGAP45

Class: DEG_SPOP_SBC_1

Location: 226:230

E3 ligase: SPOP

DEGRON score: 0.9874

ASA_SCORE: 68.74

COIL: 0.8288

CONS_SCORE: 0.286

DSS_SCORE: 0.3837

HELIX: 0.143

FCONS_SCORE: 0.9009

RIG_SCORE: 0.7797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T225M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VDSST	DEG_SPOP_SBC_1	0.3056
p.I226T	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	VDSST	DEG_SPOP_SBC_1	0.7078
p.I226T	NCI-H838	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	0.7078
p.V216M	NCI-H847	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	0.0556
p.D230N	NCI-H1944	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	0.6932
p.A220V	SNU-175	large_intestine	COSMIC	VDSST	DEG_SPOP_SBC_1	0.1667
p.A220V	HCT-116	large_intestine	COSMIC	VDSST	DEG_SPOP_SBC_1	0.1667
p.R221W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VDSST	DEG_SPOP_SBC_1	0.1944
p.I237T	NCI-H838	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	0.1389
p.G233E	NCI-H510A	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13615	Myotubularin-related protein 3	DEG_SPOP_SBC_1	842:846	VDSST	SPOP	0.9926	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	2335:2339	VDSST	SPOP	0.9382	More...
Q92619	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1	DEG_SPOP_SBC_1	226:230	VDSST	SPOP	0.9874	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	365:369	VDSST	SPOP	0.5207	More...
Q9BQE9	B-cell CLL/lymphoma 7 protein family member B	DEG_SPOP_SBC_1	105:109	VDSST	SPOP	0.9379	More...
Q6IEE7	Transmembrane protein 132E	DEG_SPOP_SBC_1	643:647	VDSST	SPOP	0.8527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons