DegronMD

Uniprot ID: Q14517

Source protein: Protocadherin Fat 1

Source gene: FAT1

Class: DEG_SPOP_SBC_1

Location: 2335:2339

E3 ligase: SPOP

DEGRON score: 0.9382

ASA_SCORE: 46.8

COIL: 0.6974

CONS_SCORE: 0.5707

DSS_SCORE: 0.2841

HELIX: 0.0148

FCONS_SCORE: 1.147

RIG_SCORE: 0.7322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2349Y	TCGA-IB-7651	PAAD	TCGA	VDSST	DEG_SPOP_SBC_1	0.0556
p.D2349Y	DO46657	PAAD	ICGC	VDSST	DEG_SPOP_SBC_1	0.0556
p.S2337R	DO228948	LICA	ICGC	VDSST	DEG_SPOP_SBC_1	0.7427
p.D2349N	DO52658	MALY	ICGC	VDSST	DEG_SPOP_SBC_1	0.0556
p.N2325S	DO36556	READ	ICGC	VDSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13615	Myotubularin-related protein 3	DEG_SPOP_SBC_1	842:846	VDSST	SPOP	0.9926	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	2335:2339	VDSST	SPOP	0.9382	More...
Q92619	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1	DEG_SPOP_SBC_1	226:230	VDSST	SPOP	0.9874	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	365:369	VDSST	SPOP	0.5207	More...
Q9BQE9	B-cell CLL/lymphoma 7 protein family member B	DEG_SPOP_SBC_1	105:109	VDSST	SPOP	0.9379	More...
Q6IEE7	Transmembrane protein 132E	DEG_SPOP_SBC_1	643:647	VDSST	SPOP	0.8527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons