DegronMD - Q92619(ARHGAP45)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L907P	SIDM01314	Colorectal Carcinoma	GDSC	LRELLRDLP	DEG_APCC_DBOX_1	891:899	Mutation rewiring degron network	0.1111
p.A601V	SIDM00216	Colorectal Carcinoma	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation altering degron motif	0.6936
p.A601V	SIDM00783	Colorectal Carcinoma	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation altering degron motif	0.6936
p.A601V	SNU-175	large intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation altering degron motif	0.6936
p.A601V	HCT-116	large intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation altering degron motif	0.6936
p.R602W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation altering degron motif	0.8634
p.R602W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation altering degron motif	0.8634
p.M10I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LMKTPSIS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.6507
p.M10I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LMKTPSIS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.6507
p.T225M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.3056
p.V597M	SIDM01149	Small Cell Lung Carcinoma	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.2778
p.V597M	NCI-H847	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.2778
p.S25G	SIDM00081	Melanoma	GDSC	LMKTPSIS	DEG_SCF_FBW7_1	9:16	Mutation blocking phosphorylation signal	0.5278
p.A20S	SIDM01064	Hodgkin's Lymphoma	GDSC	LMKTPSIS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.G614E	SIDM00927	Small Cell Lung Carcinoma	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.1111
p.G614E	NCI-H510A	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.1111
p.I226T	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7078
p.I226T	NCI-H838	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.7078
p.R590W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.0833
p.G598E	NCI-H510A	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.3056
p.A589V	HCT-116	large intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.0556
p.A589V	SNU-175	large intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.0556
p.P597T	COLO-679	skin	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.2778
p.S591F	H513	pleura	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.1111
p.V216M	NCI-H847	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.0556
p.A612V	SNU-175	large intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.1667
p.A612V	HCT-116	large intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.1667
p.R613W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.1389
p.D230N	NCI-H1944	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation altering degron motif	0.6932
p.A220V	SNU-175	large intestine	COSMIC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.A220V	HCT-116	large intestine	COSMIC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.G602E	NCI-H510A	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation altering degron motif	0.6087
p.V603I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation altering degron motif	0.7076
p.A594T	D-566MG	central nervous system	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.1944
p.E610V	HT55	large intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.2222
p.V608M	NCI-H847	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	599:606	Mutation rewiring degron network	0.2778
p.R221W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1944
p.I237T	NCI-H838	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1389
p.G233E	NCI-H510A	lung	COSMIC	VDSST	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25

Kaplan plot for ARHGAP45 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP45

UniProt ID: Q92619

Entrez ID: 23526

Protein name: Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP45 in