DegronMD

Uniprot ID: Q92619

Source protein: Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1

Source gene: ARHGAP45

Class: DEG_SCF_FBW7_1

Location: 9:16

E3 ligase: FBXW7

DEGRON score: 0.9477

ASA_SCORE: 91.3875

COIL: 0.7098

CONS_SCORE: 0.3045

DSS_SCORE: 0.7688

HELIX: 0.2315

FCONS_SCORE: 1.1017

RIG_SCORE: 0.6642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M10I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LMKTPSIS	DEG_SCF_FBW7_1	0.6507
p.M10I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LMKTPSIS	DEG_SCF_FBW7_1	0.6507
p.S25G	SIDM00081	Melanoma	GDSC	LMKTPSIS	DEG_SCF_FBW7_1	0.5278
p.A20S	SIDM01064	Hodgkin's Lymphoma	GDSC	LMKTPSIS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92619	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1	DEG_SCF_FBW7_1	9:16	LMKTPSIS	FBXW7	0.9477	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons