DegronMD

Uniprot ID: Q92619

Source protein: Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1

Source gene: ARHGAP45

Class: DEG_SCF_SKP2-CKS1_1

Location: 599:606

E3 ligase: SKP2,CSK1

DEGRON score: 0.9677

ASA_SCORE: 79.35

COIL: 0.8486

CONS_SCORE: 0.2671

DSS_SCORE: 0.7275

HELIX: 0.0659

FCONS_SCORE: 0.9018

RIG_SCORE: 0.6161

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A601V	SIDM00216	Colorectal Carcinoma	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6936
p.A601V	SIDM00783	Colorectal Carcinoma	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6936
p.A601V	SNU-175	large_intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6936
p.A601V	HCT-116	large_intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6936
p.R602W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.8634
p.R602W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.8634
p.V597M	SIDM01149	Small Cell Lung Carcinoma	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.V597M	NCI-H847	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.G614E	SIDM00927	Small Cell Lung Carcinoma	GDSC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1111
p.G614E	NCI-H510A	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R590W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.0833
p.G598E	NCI-H510A	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A589V	HCT-116	large_intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.A589V	SNU-175	large_intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P597T	COLO-679	skin	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.S591F	H513	pleura	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1111
p.A612V	SNU-175	large_intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A612V	HCT-116	large_intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R613W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1389
p.G602E	NCI-H510A	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6087
p.V603I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.7076
p.A594T	D-566MG	central_nervous_system	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E610V	HT55	large_intestine	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.V608M	NCI-H847	lung	COSMIC	CTEGTPAK	DEG_SCF_SKP2-CKS1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CTEGTPAK

Degron related mutations and impact score

Drug responses associated with ARHGAP45 mutations

All proteins holding degron of CTEGTPAK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92619	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1	DEG_SCF_SKP2-CKS1_1	599:606	CTEGTPAK	SKP2,CSK1	0.9677	More...