DegronMD

Uniprot ID: Q9BQE9

Source protein: B-cell CLL/lymphoma 7 protein family member B

Source gene: BCL7B

Class: DEG_SPOP_SBC_1

Location: 105:109

E3 ligase: SPOP

DEGRON score: 0.9379

ASA_SCORE: 91.36

COIL: 0.8934

CONS_SCORE: 0.5158

DSS_SCORE: 0.6367

HELIX: 0.083

FCONS_SCORE: 0.9931

RIG_SCORE: 0.6229

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S108R	DO229006	LICA	ICGC	VDSST	DEG_SPOP_SBC_1	0.8538
p.T114I	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VDSST	DEG_SPOP_SBC_1	0.6389
p.D106E	DO229045	LICA	ICGC	VDSST	DEG_SPOP_SBC_1	0.5647
p.S96F	TCGA-EE-A20F	SKCM	TCGA	VDSST	DEG_SPOP_SBC_1	0.0833
p.S96F	DO37961	SKCM	ICGC	VDSST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQE9	B-cell CLL/lymphoma 7 protein family member B	DEG_SPOP_SBC_1	105:109	VDSST	SPOP	0.9379	More...
Q13615	Myotubularin-related protein 3	DEG_SPOP_SBC_1	842:846	VDSST	SPOP	0.9926	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	2335:2339	VDSST	SPOP	0.9382	More...
Q92619	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1	DEG_SPOP_SBC_1	226:230	VDSST	SPOP	0.9874	More...
Q6IEE7	Transmembrane protein 132E	DEG_SPOP_SBC_1	643:647	VDSST	SPOP	0.8527	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	365:369	VDSST	SPOP	0.5207	More...

Showing 1 to 6 of 6 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons