DegronMD

Uniprot ID: Q13615

Source protein: Myotubularin-related protein 3

Source gene: MTMR3

Class: LIG_APCC_ABBA_1

Location: 737:742

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8998

ASA_SCORE: 82.95

COIL: 0.7848

CONS_SCORE: 0.2854

DSS_SCORE: 0.5965

HELIX: 0.1718

FCONS_SCORE: 0.9636

RIG_SCORE: 0.6894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H728Y	DO219095	BLCA	ICGC	IGLHQD	LIG_APCC_ABBA_1	0.0833
p.P748L	DO48665	SKCM	ICGC	IGLHQD	LIG_APCC_ABBA_1	0.1667
p.P748H	DO38165	SKCM	ICGC	IGLHQD	LIG_APCC_ABBA_1	0.1667
p.Q742H	DO229275	THCA	ICGC	IGLHQD	LIG_APCC_ABBA_1	0.7582
p.S727N	SIDM01451	Pancreatic Carcinoma	GDSC	IGLHQD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13615	Myotubularin-related protein 3	LIG_APCC_ABBA_1	737:742	IGLHQD	APC,CDC20,FZR1	0.8998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons