DegronMD

Uniprot ID: Q96K83

Source protein: Zinc finger protein 521

Source gene: ZNF521

Class: DEG_SCF_FBW7_1

Location: 1173:1179

E3 ligase: FBXW7

DEGRON score: 0.9638

ASA_SCORE: 74.8857

COIL: 0.8333

CONS_SCORE: 0.4797

DSS_SCORE: 0.6761

HELIX: 0.0056

FCONS_SCORE: 0.837

RIG_SCORE: 0.6716

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1173M	TCGA-13-0886	OV	TCGA	LKTPQVS	DEG_SCF_FBW7_1	0.5999
p.L1173M	DO30250	OV	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.5999
p.N1169K	TCGA-28-1760	GBM	TCGA	LKTPQVS	DEG_SCF_FBW7_1	0.2222
p.N1169K	DO13725	GBM	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.2222
p.S1170N	TCGA-AA-A01R	COAD	TCGA	LKTPQVS	DEG_SCF_FBW7_1	0.25
p.S1170N	DO7934	COAD	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.25
p.R1183K	TCGA-AC-A23H	BRCA	TCGA	LKTPQVS	DEG_SCF_FBW7_1	0.2222
p.R1183K	DO2401	BRCA	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.2222
p.I1184T	TCGA-AJ-A23O	UCEC	TCGA	LKTPQVS	DEG_SCF_FBW7_1	0.1944
p.I1184T	DO43290	UCEC	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.1944
p.S1185N	TCGA-B5-A11E	UCEC	TCGA	LKTPQVS	DEG_SCF_FBW7_1	0.6111
p.S1185N	DO41644	UCEC	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.6111
p.Q1188R	TCGA-BR-8078	STAD	TCGA	LKTPQVS	DEG_SCF_FBW7_1	0.0833
p.Q1188R	DO38288	STAD	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.0833
p.T1175M	TCGA-XK-AAJP	PRAD	TCGA	LKTPQVS	DEG_SCF_FBW7_1	0.7423
p.T1175M	DO233941	GACA	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.7423
p.T1175M	DO51410	PRAD	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.7423
p.S1189L	DO234425	ESAD	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.0556
p.L1164F	DO232761	PBCA	ICGC	LKTPQVS	DEG_SCF_FBW7_1	0.0833
p.S1170G	SIDM00776	Colorectal Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	0.25
p.S1170G	SIDM00782	Colorectal Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	0.25
p.S1170G	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	0.25
p.S1170R	SIDM01162	Kidney Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	0.25
p.S1170R	ACH-001398	Kidney Cancer	CCLE	LKTPQVS	DEG_SCF_FBW7_1	0.25
p.S1170R	SW156	kidney	COSMIC	LKTPQVS	DEG_SCF_FBW7_1	0.25
p.V1165M	SIDM00068	Colorectal Carcinoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	0.1111
p.V1165M	GEO	large_intestine	COSMIC	LKTPQVS	DEG_SCF_FBW7_1	0.1111
p.I1184M	SIDM00622	Glioblastoma	GDSC	LKTPQVS	DEG_SCF_FBW7_1	0.1944
p.I1184M	D-247MG	central_nervous_system	COSMIC	LKTPQVS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKTPQVS

Degron related mutations and impact score

Drug responses associated with ZNF521 mutations

All proteins holding degron of LKTPQVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K83	Zinc finger protein 521	DEG_SCF_FBW7_1	1173:1179	LKTPQVS	FBXW7	0.9638	More...