DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VSSTT
Uniprot ID:
Q8TBY9
Source protein:
Cilia- and flagella-associated protein 251
Source gene:
CFAP251
Class:
DEG_SPOP_SBC_1
Location:
229:233
E3 ligase:
SPOP
DEGRON score:
0.9658
ASA_SCORE:
57.72
COIL:
0.7082
CONS_SCORE:
0.1345
DSS_SCORE:
0.3851
HELIX:
0.0918
FCONS_SCORE:
0.9323
RIG_SCORE:
0.7335
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CFAP251 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14974
Protein phosphatase 1 regulatory subunit 12A
DEG_SPOP_SBC_1
656:660
VSSTT
SPOP
0.9967
More...
Q15398
Disks large-associated protein 5
DEG_SPOP_SBC_1
220:224
VSSTT
SPOP
0.781
More...
Q3SXY7
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
DEG_SPOP_SBC_1
420:424
VSSTT
SPOP
0.9437
More...
Q8NHH9
Atlastin-2
DEG_SPOP_SBC_1
33:37
VSSTT
SPOP
0.999
More...
Q8TBY9
Cilia- and flagella-associated protein 251
DEG_SPOP_SBC_1
229:233
VSSTT
SPOP
0.9658
More...
Q8TC05
Nuclear protein MDM1
DEG_SPOP_SBC_1
373:377
VSSTT
SPOP
0.9916
More...
Q8TF66
Leucine-rich repeat-containing protein 15
DEG_SPOP_SBC_1
502:506
VSSTT
SPOP
0.584
More...
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SPOP_SBC_1
1165:1169
VSSTT
SPOP
0.9972
More...
Q96K83
Zinc finger protein 521
DEG_SPOP_SBC_1
354:358
VSSTT
SPOP
0.9025
More...
Q9H7N4
Splicing factor, arginine/serine-rich 19
DEG_SPOP_SBC_1
845:849
VSSTT
SPOP
0.9657
More...
A6NMB9
Fidgetin-like protein 2
DEG_SPOP_SBC_1
21:25
VSSTT
SPOP
0.9977
More...