DegronMD

Uniprot ID: Q9H7N4

Source protein: Splicing factor, arginine/serine-rich 19

Source gene: SCAF1

Class: LIG_APCC_ABBA_1

Location: 447:452

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8297

ASA_SCORE: 86.2

COIL: 0.7132

CONS_SCORE: 0.4854

DSS_SCORE: 0.7703

HELIX: 0.23

FCONS_SCORE: 0.9856

RIG_SCORE: 0.6708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E442K	DO46384	OV	ICGC	LSLHAE	LIG_APCC_ABBA_1	0.1944
p.S448F	DO218855	SKCA	ICGC	LSLHAE	LIG_APCC_ABBA_1	0.7982
p.D444G	SIDM02026	Colorectal Carcinoma	GDSC	LSLHAE	LIG_APCC_ABBA_1	0.25
p.A458T	ACH-000973	Bladder Cancer	CCLE	LSLHAE	LIG_APCC_ABBA_1	0.1667
p.E452Q	ACH-001402	Cervical Cancer	CCLE	LSLHAE	LIG_APCC_ABBA_1	0.6744
p.S453P	ACH-001735	Leukemia	CCLE	LSLHAE	LIG_APCC_ABBA_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7N4	Splicing factor, arginine/serine-rich 19	LIG_APCC_ABBA_1	447:452	LSLHAE	APC,CDC20,FZR1	0.8297	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons