DegronMD

Uniprot ID: Q8TAQ2

Source protein: SWI/SNF complex subunit SMARCC2

Source gene: SMARCC2

Class: DEG_SCF_FBW7_1

Location: 546:552

E3 ligase: FBXW7

DEGRON score: 0.7887

ASA_SCORE: 94.7857

COIL: 0.8997

CONS_SCORE: 0.2806

DSS_SCORE: 0.7489

HELIX: 0.0609

FCONS_SCORE: 0.7208

RIG_SCORE: 0.6549

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S553F	TCGA-K4-A5RH	BLCA	TCGA	PKTPQQT	DEG_SCF_FBW7_1	0.75
p.S553F	DO219028	BLCA	ICGC	PKTPQQT	DEG_SCF_FBW7_1	0.75
p.T552I	TCGA-AJ-A8CT	UCEC	TCGA	PKTPQQT	DEG_SCF_FBW7_1	0.7078
p.T552I	DO52399	UCEC	ICGC	PKTPQQT	DEG_SCF_FBW7_1	0.7078
p.D555Y	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PKTPQQT	DEG_SCF_FBW7_1	0.6944
p.D555Y	NCI-H2347	lung	COSMIC	PKTPQQT	DEG_SCF_FBW7_1	0.6944
p.V542L	TCGA-C8-A12K	BRCA	TCGA	PKTPQQT	DEG_SCF_FBW7_1	0.2222
p.V542L	DO1258	BRCA	ICGC	PKTPQQT	DEG_SCF_FBW7_1	0.2222
p.D536N	TCGA-C8-A26Y	BRCA	TCGA	PKTPQQT	DEG_SCF_FBW7_1	0.0556
p.D536N	DO1273	BRCA	ICGC	PKTPQQT	DEG_SCF_FBW7_1	0.0556
p.P562A	DO51955	PRAD	ICGC	PKTPQQT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SCF_FBW7_1	546:552	PKTPQQT	FBXW7	0.7887	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons