DegronMD

Uniprot ID: Q8TAQ2

Source protein: SWI/SNF complex subunit SMARCC2

Source gene: SMARCC2

Class: DEG_SPOP_SBC_1

Location: 741:745

E3 ligase: SPOP

DEGRON score: 0.9966

ASA_SCORE: 60.6

COIL: 0.8252

CONS_SCORE: 0.2553

DSS_SCORE: 0.6784

HELIX: 0.0852

FCONS_SCORE: 1.0528

RIG_SCORE: 0.6158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S737R	TCGA-CM-6163	COAD	TCGA	AGTTS	DEG_SPOP_SBC_1	0.2222
p.S737R	DO9194	COAD	ICGC	AGTTS	DEG_SPOP_SBC_1	0.2222
p.S754C	DO52438	COCA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.5278
p.E753Q	DO222734	ESCA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.1111
p.G755R	DO228947	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0556
p.P731T	DO229045	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0556
p.L735Q	DO23298	LINC	ICGC	AGTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	974:978	AGTTS	SPOP	0.9922	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	215:219	AGTTS	SPOP	0.9938	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	741:745	AGTTS	SPOP	0.9966	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	491:495	AGTTS	SPOP	0.9528	More...
Q96JP5	E3 ubiquitin-protein ligase ZFP91	DEG_SPOP_SBC_1	42:46	AGTTS	SPOP	0.9924	More...
Q99959	Plakophilin-2	DEG_SPOP_SBC_1	205:209	AGTTS	SPOP	0.9955	More...
Q9H228	Sphingosine 1-phosphate receptor 5	DEG_SPOP_SBC_1	233:237	AGTTS	SPOP	0.7632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons