ZFP91
UniProt ID: Q96JP5
Entrez ID: 80829
Protein name: E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti...
FUNCTION: Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}.
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GO - Biological processes (BP):
activation of NF-kappaB-inducing kinase activity [GO:0007250]; protein K63-linked ubiquitination [GO:0070534]; regulation of transcription by RNA polymerase II [GO:0006357]...
activation of NF-kappaB-inducing kinase activity [GO:0007250]; protein K63-linked ubiquitination [GO:0070534]; regulation of transcription by RNA polymerase II [GO:0006357]
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GO - Molecular function (MF):
metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]...
metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]
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GO - Cellular component (CC):
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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ZFP91
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*NOTE: the Kaplan plots were collected from OncoLnc