DegronMD

Uniprot ID: Q96JP5

Source protein: E3 ubiquitin-protein ligase ZFP91

Source gene: ZFP91

Class: DEG_SPOP_SBC_1

Location: 42:46

E3 ligase: SPOP

DEGRON score: 0.9924

ASA_SCORE: 79.38

COIL: 0.9312

CONS_SCORE: 0.5415

DSS_SCORE: 0.6448

HELIX: 0.0428

FCONS_SCORE: 0.9493

RIG_SCORE: 0.6362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R56L	DO477	BLCA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0556
p.E35Q	ACH-000785	Lung Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	0.1389
p.G53A	ACH-000901	Lung Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	974:978	AGTTS	SPOP	0.9922	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	215:219	AGTTS	SPOP	0.9938	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	741:745	AGTTS	SPOP	0.9966	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	491:495	AGTTS	SPOP	0.9528	More...
Q96JP5	E3 ubiquitin-protein ligase ZFP91	DEG_SPOP_SBC_1	42:46	AGTTS	SPOP	0.9924	More...
Q99959	Plakophilin-2	DEG_SPOP_SBC_1	205:209	AGTTS	SPOP	0.9955	More...
Q9H228	Sphingosine 1-phosphate receptor 5	DEG_SPOP_SBC_1	233:237	AGTTS	SPOP	0.7632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons