DegronMD

Uniprot ID: Q9H228

Source protein: Sphingosine 1-phosphate receptor 5

Source gene: S1PR5

Class: DEG_SPOP_SBC_1

Location: 233:237

E3 ligase: SPOP

DEGRON score: 0.7632

ASA_SCORE: 89.5

COIL: 0.9192

CONS_SCORE: 0.4798

DSS_SCORE: 0.6109

HELIX: 0.0684

FCONS_SCORE: 0.6131

RIG_SCORE: 0.6828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G231E	TCGA-2G-AAGM	TGCT	TCGA	AGTTS	DEG_SPOP_SBC_1	0.2778
p.R224W	TCGA-AD-6895	COAD	TCGA	AGTTS	DEG_SPOP_SBC_1	0.0833
p.R224W	DO8938	COAD	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0833
p.A223T	DO10842	ESAD	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0556
p.A223T	DO233737	GACA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0556
p.A233V	DO233855	GACA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.5825
p.R229L	SIDM02015	Colorectal Carcinoma	GDSC	AGTTS	DEG_SPOP_SBC_1	0.2222
p.R239Q	SIDM00683	Prostate Carcinoma	GDSC	AGTTS	DEG_SPOP_SBC_1	0.2778
p.S237L	SIDM00683	Prostate Carcinoma	GDSC	AGTTS	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	974:978	AGTTS	SPOP	0.9922	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	215:219	AGTTS	SPOP	0.9938	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	741:745	AGTTS	SPOP	0.9966	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	491:495	AGTTS	SPOP	0.9528	More...
Q96JP5	E3 ubiquitin-protein ligase ZFP91	DEG_SPOP_SBC_1	42:46	AGTTS	SPOP	0.9924	More...
Q99959	Plakophilin-2	DEG_SPOP_SBC_1	205:209	AGTTS	SPOP	0.9955	More...
Q9H228	Sphingosine 1-phosphate receptor 5	DEG_SPOP_SBC_1	233:237	AGTTS	SPOP	0.7632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons