DegronMD - Q86YV5(PRAG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E362K	SIDM02043	Colorectal Carcinoma	GDSC	FVPHLE	LIG_APCC_ABBA_1	357:362	Mutation altering degron motif	0.7022
p.M369V	SIDM01307	Colorectal Carcinoma	GDSC	FVPHLE	LIG_APCC_ABBA_1	357:362	Mutation rewiring degron network	0.1389
p.R1274G	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	1281:1283	Mutation rewiring degron network	0.1389
p.R1274G	SIDM00807	Bladder Carcinoma	GDSC	DYR	CBL_MET	1281:1283	Mutation rewiring degron network	0.1389
p.R1274G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	1281:1283	Mutation rewiring degron network	0.1389
p.R1274G	SIDM00720	Mesothelioma	GDSC	DYR	CBL_MET	1281:1283	Mutation rewiring degron network	0.1389
p.R1274G	SIDM01318	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	1281:1283	Mutation rewiring degron network	0.1389
p.R1274G	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	1281:1283	Mutation rewiring degron network	0.1389
p.R1274C	SIDM00214	Colorectal Carcinoma	GDSC	DYR	CBL_MET	1281:1283	Mutation rewiring degron network	0.1389
p.R1274C	SNU-407	large intestine	COSMIC	DYR	CBL_MET	1281:1283	Mutation rewiring degron network	0.1389
p.D364Y	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	FVPHLE	LIG_APCC_ABBA_1	357:362	Mutation rewiring degron network	0.2778
p.D364Y	LC-1-sq	lung	COSMIC	FVPHLE	LIG_APCC_ABBA_1	357:362	Mutation rewiring degron network	0.2778
p.S867R	SIDM01577	Plasma Cell Myeloma	GDSC	DESHFSYSLSP	CBL_PTK	858:868	Mutation altering degron motif	0.7427
p.R461L	SIDM01782	Oral Cavity Carcinoma	GDSC	PDPTPQVS	DEG_SCF_FBW7_1	464:471	Mutation rewiring degron network	0.25
p.P466S	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PDPTPQVS	DEG_SCF_FBW7_1	464:471	Mutation altering degron motif	0.5641

Kaplan plot for PRAG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRAG1

UniProt ID: Q86YV5

Entrez ID: 157285

Protein name: Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRAG1 in