DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DESHFSYSLSP
Uniprot ID:
Q86YV5
Source protein:
Inactive tyrosine-protein kinase PRAG1
Source gene:
PRAG1
Class:
CBL_PTK
Location:
858:868
E3 ligase:
CBL
DEGRON score:
0.9584
ASA_SCORE:
87.4818
COIL:
0.859
CONS_SCORE:
0.3449
DSS_SCORE:
0.5224
HELIX:
0.0995
FCONS_SCORE:
0.8007
RIG_SCORE:
0.6382
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S867R
SIDM01577
Plasma Cell Myeloma
GDSC
DESHFSYSLSP
CBL_PTK
0.7427
Drug responses associated with PRAG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DESHFSYSLSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86YV5
Inactive tyrosine-protein kinase PRAG1
CBL_PTK
858:868
DESHFSYSLSP
CBL
0.9584
More...
