DegronMD

Uniprot ID: Q86YV5

Source protein: Inactive tyrosine-protein kinase PRAG1

Source gene: PRAG1

Class: DEG_SCF_FBW7_1

Location: 464:471

E3 ligase: FBXW7

DEGRON score: 0.9917

ASA_SCORE: 96.725

COIL: 0.9375

CONS_SCORE: 0.4346

DSS_SCORE: 0.6028

HELIX: 0.0266

FCONS_SCORE: 0.9834

RIG_SCORE: 0.6598

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R461L	SIDM01782	Oral Cavity Carcinoma	GDSC	PDPTPQVS	DEG_SCF_FBW7_1	0.25
p.P466S	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PDPTPQVS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SCF_FBW7_1	464:471	PDPTPQVS	FBXW7	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons