DegronMD

Uniprot ID: Q86YV5

Source protein: Inactive tyrosine-protein kinase PRAG1

Source gene: PRAG1

Class: LIG_APCC_ABBA_1

Location: 357:362

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.985

ASA_SCORE: 105.5667

COIL: 0.9247

CONS_SCORE: 0.427

DSS_SCORE: 0.4092

HELIX: 0.0447

FCONS_SCORE: 1.1683

RIG_SCORE: 0.6934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E362K	SIDM02043	Colorectal Carcinoma	GDSC	FVPHLE	LIG_APCC_ABBA_1	0.7022
p.M369V	SIDM01307	Colorectal Carcinoma	GDSC	FVPHLE	LIG_APCC_ABBA_1	0.1389
p.D364Y	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	FVPHLE	LIG_APCC_ABBA_1	0.2778
p.D364Y	LC-1-sq	lung	COSMIC	FVPHLE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YV5	Inactive tyrosine-protein kinase PRAG1	LIG_APCC_ABBA_1	357:362	FVPHLE	APC,CDC20,FZR1	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons