DegronMD

Uniprot ID: Q99959

Source protein: Plakophilin-2

Source gene: PKP2

Class: DEG_APCC_KENBOX_2

Location: 257:261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9626

ASA_SCORE: 97.44

COIL: 0.6194

CONS_SCORE: 0.3912

DSS_SCORE: 0.3533

HELIX: 0.3258

FCONS_SCORE: 0.9997

RIG_SCORE: 0.8006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S251C	TCGA-44-8117	LUAD	TCGA	EKENY	DEG_APCC_KENBOX_2	0.6111
p.S251C	DO24028	LUAD	ICGC	EKENY	DEG_APCC_KENBOX_2	0.6111
p.R250G	TCGA-55-A4DG	LUAD	TCGA	EKENY	DEG_APCC_KENBOX_2	0.1389
p.R250G	DO26337	LUAD	ICGC	EKENY	DEG_APCC_KENBOX_2	0.1389
p.A264T	TCGA-AP-A1DK	UCEC	TCGA	EKENY	DEG_APCC_KENBOX_2	0.25
p.A264T	DO42033	UCEC	ICGC	EKENY	DEG_APCC_KENBOX_2	0.25
p.T263M	TCGA-BR-4361	STAD	TCGA	EKENY	DEG_APCC_KENBOX_2	0.7222
p.T263M	DO38887	STAD	ICGC	EKENY	DEG_APCC_KENBOX_2	0.7222
p.G269R	TCGA-DH-A7UR	LGG	TCGA	EKENY	DEG_APCC_KENBOX_2	0.1111
p.G269R	DO51809	LGG	ICGC	EKENY	DEG_APCC_KENBOX_2	0.1111
p.G269R	DO34288	PACA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.1111
p.N254K	DO7214	CLLE	ICGC	EKENY	DEG_APCC_KENBOX_2	0.25
p.N254K	DO229015	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.25
p.T263K	DO229037	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.7222
p.L262V	DO44754	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.3056
p.G253D	DO222908	MELA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.2222
p.A264V	SIDM00087	Plasma Cell Myeloma	GDSC	EKENY	DEG_APCC_KENBOX_2	0.25
p.A264V	SIDM00971	Breast Carcinoma	GDSC	EKENY	DEG_APCC_KENBOX_2	0.25
p.A264V	SIDM01133	Other Solid Cancers	GDSC	EKENY	DEG_APCC_KENBOX_2	0.25
p.A264V	SIDM00628	Breast Carcinoma	GDSC	EKENY	DEG_APCC_KENBOX_2	0.25
p.A264V	SIDM01686	Chronic Myelogenous Leukemia	GDSC	EKENY	DEG_APCC_KENBOX_2	0.25
p.R250L	SIDM00223	Small Cell Lung Carcinoma	GDSC	EKENY	DEG_APCC_KENBOX_2	0.1389
p.R250L	ACH-002144	Lung Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	0.1389
p.R250L	IST-SL1	lung	COSMIC	EKENY	DEG_APCC_KENBOX_2	0.1389
p.G269E	ACH-001554	Eye Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42331	Rho GTPase-activating protein 25	DEG_APCC_KENBOX_2	579:583	EKENY	APC,CDC20,FZR1	0.988	More...
Q99959	Plakophilin-2	DEG_APCC_KENBOX_2	257:261	EKENY	APC,CDC20,FZR1	0.9626	More...
Q9NV35	Nucleotide triphosphate diphosphatase NUDT15	DEG_APCC_KENBOX_2	86:90	EKENY	APC,CDC20,FZR1	0.6218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons